Protein nutrition governs within-host race of honey bee pathogens

Tritschler, Manuel; Vollmann, Jutta J.; Yanez Amayo, Victor Orlando; Chejanovsky, Nor; Crailsheim, Karl; Neumann, Peter (2017). Protein nutrition governs within-host race of honey bee pathogens. Scientific Reports, 7(1), p. 14988. Nature Publishing Group 10.1038/s41598-017-15358-w

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Multiple infections are common in honey bees, Apis mellifera, but the possible role of nutrition in this regard is poorly understood. Microsporidian infections, which are promoted by protein-fed, can negatively correlate with virus infections, but the role of protein nutrition for the microsporidian-virus interface is unknown. Here, we challenged naturally deformed wing virus - B (DWV-B) infected adult honey bee workers fed with or without pollen ( = protein) in hoarding cages, with the microsporidian Nosema ceranae. Bee mortality was recorded for 14 days and N. ceranae spore loads and DWV-B titers were quantified. Amongst the groups inoculated with N. ceranae, more spores were counted in protein-fed bees. However, N. ceranae infected bees without protein-diet had reduced longevity compared to all other groups. N. ceranae infection had no effect on protein-fed bee's longevity, whereas bees supplied only with sugar-water showed reduced survival. Our data also support that protein-feeding can have a significant negative impact on virus infections in insects. The negative correlation between N. ceranae spore loads and DWV-B titers was stronger expressed in protein-fed hosts. Proteins not only enhance survival of infected hosts, but also significantly shape the microsporidian-virus interface, probably due to increased spore production and enhanced host immunity.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Institute of Bee Health
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH)

UniBE Contributor:

Tritschler, Manuel; Yanez Amayo, Victor Orlando; Chejanovsky, Nor and Neumann, Peter

Subjects:

500 Science > 590 Animals (Zoology)
600 Technology > 630 Agriculture

ISSN:

2045-2322

Publisher:

Nature Publishing Group

Language:

English

Submitter:

Anna Papach

Date Deposited:

22 May 2018 16:17

Last Modified:

15 Mar 2021 10:24

Publisher DOI:

10.1038/s41598-017-15358-w

PubMed ID:

29118416

BORIS DOI:

10.7892/boris.113650

URI:

https://boris.unibe.ch/id/eprint/113650

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