Evaluation of the effects of space allowance on measures of animal welfare in laboratory mice.

Bailoo, Jeremy Davidson; Murphy, Eimear Mary; Varholick, Justin Adam; Novak, Janja; Palme, Rupert; Würbel, Hanno (2018). Evaluation of the effects of space allowance on measures of animal welfare in laboratory mice. Scientific Reports, 8(1), p. 713. Nature Publishing Group 10.1038/s41598-017-18493-6

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We studied how space allowance affects measures of animal welfare in mice by systematically varying group size and cage type across three levels each in both males and females of two strains of mice (C57BL/6ByJ and BALB/cByJ; n = 216 cages, a total of 1152 mice). This allowed us to disentangle the effects of total floor area, group size, stocking density, and individual space allocation on a broad range of measures of welfare, including growth (food and water intake, body mass); stress physiology (glucocorticoid metabolites in faecal boli); emotionality (open field behaviour); brain function (recurrent perseveration in a two-choice guessing task); and home-cage behaviour (activity, stereotypic behaviour). While increasing group size was associated with a decrease in food and water intake in general, and more specifically with increased attrition due to escalated aggression in male BALB mice, no other consistent effects of any aspect of space allowance were found with respect to the measures studied here. Our results indicate that within the range of conditions commonly found in laboratory mouse housing, space allowance as such has little impact on measures of welfare, except for group size which may be a risk factor for escalating aggression in males of some strains.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Veterinary Public Health Institute > Animal Welfare Division
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Veterinary Public Health Institute
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH)

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Bailoo, Jeremy Davidson; Murphy, Eimear Mary; Varholick, Justin Adam; Novak, Janja and Würbel, Hanno

Subjects:

600 Technology > 630 Agriculture

ISSN:

2045-2322

Publisher:

Nature Publishing Group

Language:

English

Submitter:

Jeremy Davidson Bailoo

Date Deposited:

12 Apr 2018 15:34

Last Modified:

25 Oct 2019 07:31

Publisher DOI:

10.1038/s41598-017-18493-6

PubMed ID:

29335423

BORIS DOI:

10.7892/boris.113664

URI:

https://boris.unibe.ch/id/eprint/113664

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