Reproducibility and replicability of rodent phenotyping in preclinical studies.

Kafkafi, Neri; Agassi, Joseph; Chesler, Elissa J; Crabbe, John C; Crusio, Wim E; Eilam, David; Gerlai, Robert; Golani, Ilan; Gomez-Marin, Alex; Heller, Ruth; Iraqi, Fuad; Jaljuli, Iman; Karp, Natasha A; Morgan, Hugh; Nicholson, George; Pfaff, Donald W; Richter, S Helene; Stark, Philip B; Stiedl, Oliver; Stodden, Victoria; ... (2018). Reproducibility and replicability of rodent phenotyping in preclinical studies. Neuroscience and biobehavioral reviews, 87, pp. 218-232. Elsevier 10.1016/j.neubiorev.2018.01.003

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The scientific community is increasingly concerned with the proportion of published "discoveries" that are not replicated in subsequent studies. The field of rodent behavioral phenotyping was one of the first to raise this concern, and to relate it to other methodological issues: the complex interaction between genotype and environment; the definitions of behavioral constructs; and the use of laboratory mice and rats as model species for investigating human health and disease mechanisms. In January 2015, researchers from various disciplines gathered at Tel Aviv University to discuss these issues. The general consensus was that the issue is prevalent and of concern, and should be addressed at the statistical, methodological and policy levels, but is not so severe as to call into question the validity and the usefulness of model organisms as a whole. Well-organized community efforts, coupled with improved data and metadata sharing, have a key role in identifying specific problems and promoting effective solutions. Replicability is closely related to validity, may affect generalizability and translation of findings, and has important ethical implications.

Item Type:

Journal Article (Review Article)

Division/Institute:

05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Veterinary Public Health Institute > Animal Welfare Division
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Veterinary Public Health Institute
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH)

UniBE Contributor:

Würbel, Hanno

Subjects:

600 Technology > 630 Agriculture

ISSN:

1873-7528

Publisher:

Elsevier

Language:

English

Submitter:

Jeremy Davidson Bailoo

Date Deposited:

12 Apr 2018 16:00

Last Modified:

23 Oct 2019 08:14

Publisher DOI:

10.1016/j.neubiorev.2018.01.003

PubMed ID:

29357292

Uncontrolled Keywords:

Data sharing False discoveries GxE interaction Heterogenization Replicability Reproducibility Validity

BORIS DOI:

10.7892/boris.113681

URI:

https://boris.unibe.ch/id/eprint/113681

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