Neurofeedback-Based Enhancement of Single-Trial Auditory Evoked Potentials: Treatment of Auditory Verbal Hallucinations in Schizophrenia.

Rieger, Kathryn; Rarra, Marie-Helene Margarete Philomena; Díaz Hernàndez, Laura; Hubl, Daniela; König, Thomas (2018). Neurofeedback-Based Enhancement of Single-Trial Auditory Evoked Potentials: Treatment of Auditory Verbal Hallucinations in Schizophrenia. Clinical EEG and neuroscience, 49(6), pp. 367-378. Sage 10.1177/1550059418765810

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Auditory verbal hallucinations depend on a broad neurobiological network ranging from the auditory system to language as well as memory-related processes. As part of this, the auditory N100 event-related potential (ERP) component is attenuated in patients with schizophrenia, with stronger attenuation occurring during auditory verbal hallucinations. Changes in the N100 component assumingly reflect disturbed responsiveness of the auditory system toward external stimuli in schizophrenia. With this premise, we investigated the therapeutic utility of neurofeedback training to modulate the auditory-evoked N100 component in patients with schizophrenia and associated auditory verbal hallucinations. Ten patients completed electroencephalography neurofeedback training for modulation of N100 (treatment condition) or another unrelated component, P200 (control condition). On a behavioral level, only the control group showed a tendency for symptom improvement in the Positive and Negative Syndrome Scale total score in a pre-/postcomparison ( t= 2.71, P = .054); however, no significant differences were found in specific hallucination related symptoms ( t= -0.53, P = .62). There was no significant overall effect of neurofeedback training on ERP components in our paradigm; however, we were able to identify different learning patterns, and found a correlation between learning and improvement in auditory verbal hallucination symptoms across training sessions ( r = 0.664, n = 9, P = .05). This effect results, with cautious interpretation due to the small sample size, primarily from the treatment group ( r = 0.97, n = 4, P = .03). In particular, a within-session learning parameter showed utility for predicting symptom improvement with neurofeedback training. In conclusion, patients with schizophrenia and associated auditory verbal hallucinations who exhibit a learning pattern more characterized by within-session aptitude may benefit from electroencephalography neurofeedback. Furthermore, independent of the training group, a significant spatial pre-post difference was found in the event-related component P200 ( P = .04).

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Translational Research Center

UniBE Contributor:

Rieger, Kathryn; Rarra, Marie-Helene Margarete Philomena; Díaz Hernàndez, Laura; Hubl, Daniela and König, Thomas

Subjects:

500 Science > 570 Life sciences; biology

ISSN:

1550-0594

Publisher:

Sage

Funders:

[UNSPECIFIED] OPO Stiftung

Language:

English

Submitter:

Thomas König

Date Deposited:

28 Mar 2018 09:08

Last Modified:

29 Oct 2019 12:04

Publisher DOI:

10.1177/1550059418765810

PubMed ID:

29569473

Uncontrolled Keywords:

N100 P200 auditory verbal hallucinations event-related potentials neurofeedback schizophrenia

BORIS DOI:

10.7892/boris.113829

URI:

https://boris.unibe.ch/id/eprint/113829

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