Elbasvir/Grazoprevir, an Alternative in Antiviral Hepatitis C Therapy in Patients under Amiodarone Treatment

Weiss, Lina; Wustmann, Kerstin Brigitte; Semmo, Mariam; Schwerzmann, Markus; Semmo, Nasser (2018). Elbasvir/Grazoprevir, an Alternative in Antiviral Hepatitis C Therapy in Patients under Amiodarone Treatment. Case reports in gastroenterology, 12(1), pp. 92-98. Karger 10.1159/000486951

[img]
Preview
Text
Amiodaron-HCV Paper.pdf - Published Version
Available under License Creative Commons: Attribution-Noncommercial (CC-BY-NC).

Download (644kB) | Preview

A sofosbuvir/ledipasvir combination is part of a first-line treatment of hepatitis C. However, in patients concurrently treated with amiodarone, cardiac side effects have been described, resulting in an official warning in 2015 by the American Food and Drug Administration and the European Medicines Agency when combining those substances. This deprived numerous hepatitis C patients with concurrent cardiovascular problems of receiving this highly effective treatment. Here we present a treatment alternative with an elbasvir/grazoprevir regimen, based on our successful treatment of a patient under concurrent amiodarone therapy. Our observations indicate that patients treated with amiodarone can finally benefit from effective antiviral therapy.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Hepatology
04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Nephrology and Hypertension

UniBE Contributor:

Wustmann, Kerstin Brigitte; Semmo, Mariam; Schwerzmann, Markus and Semmo, Nasser

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1662-0631

Publisher:

Karger

Language:

English

Submitter:

Markus Schwerzmann

Date Deposited:

23 Apr 2018 12:51

Last Modified:

29 May 2019 09:48

Publisher DOI:

10.1159/000486951

PubMed ID:

29606942

BORIS DOI:

10.7892/boris.114105

URI:

https://boris.unibe.ch/id/eprint/114105

Actions (login required)

Edit item Edit item
Provide Feedback