Acetazolamide Reduces Retinal Inner Nuclear Layer Thickness in Microcystic Macular Edema Secondary to Optic Neuropathy.

Borruat, François-Xavier; Dysli, Muriel; Voide, Nathalie; Abegg, Mathias (2018). Acetazolamide Reduces Retinal Inner Nuclear Layer Thickness in Microcystic Macular Edema Secondary to Optic Neuropathy. European neurology, 79(3-4), pp. 150-153. Karger 10.1159/000487665

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Optic neuropathy (ON) is commonly complicated by microcystic macular edema (MME), that is, small vertical cystoid spaces in the inner nuclear layer (INL) of the macula. We performed a retrospective consecutive case series of 14 eyes from 11 patients with ON and MME that were treated with oral acetazolamide, acting on cellular water transport. Contralateral eyes without MME were used as controls. Segmentation of images obtained with OCT was used to determine changes of individual retinal layer thickness during treatment. Retinal INL thickness consistently decreased in all eyes after 2-3 weeks of treatment. Recurrence of MME was observed after treatment cessation. No significant change of retinal thickness was found in contralateral unaffected eyes. Visual function did not change with treatment. Acetazolamide significantly improved the MME in eyes with ON. However, visual function did not. Acetazolamide is a treatment option for MME associated with ON but without an impact on the visual function.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ophthalmology

UniBE Contributor:

Abegg, Mathias

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0014-3022

Publisher:

Karger

Language:

English

Submitter:

Mathias Abegg

Date Deposited:

24 Apr 2018 14:00

Last Modified:

26 May 2018 01:32

Publisher DOI:

10.1159/000487665

PubMed ID:

29514169

Uncontrolled Keywords:

Acetazolamide Microcystic macular edema Optic neuropathy Optical coherence tomography segmentation Retinal inner nuclear layer

URI:

https://boris.unibe.ch/id/eprint/114539

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