A Cartography of Siglecs and Sialyltransferases in Gynecologic Malignancies: Is There a Road Towards a Sweet Future?

Haas, Quentin; Simillion, Cedric André Marie; von Gunten, Stephan (2018). A Cartography of Siglecs and Sialyltransferases in Gynecologic Malignancies: Is There a Road Towards a Sweet Future? Frontiers in oncology, 8, p. 68. Frontiers Research Foundation 10.3389/fonc.2018.00068

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Altered surface glycosylation is a key feature of cancers, including gynecologic malignancies. Hypersialylation, the overexpression of sialic acid, is known to promote tumor progression and to dampen antitumor responses by mechanisms that also involve sialic acid binding immunoglobulin-like lectins (Siglecs), inhibitory immune receptors. Here, we discuss the expression patterns of Siglecs and sialyltransferases (STs) in gynecologic cancers, including breast, ovarian, and uterine malignancies, based on evidence from The Cancer Genome Atlas. The balance between sialosides generated by specific STs within the tumor microenvironment and Siglecs on leukocytes may play a decisive role for antitumor immunity. An interdisciplinary effort is required to decipher the characteristics and biological impact of the altered tumor sialome in gynecologic cancers and to exploit this knowledge to the clinical benefit of patients.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR)
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Pharmacology

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Haas, Quentin; Simillion, Cedric André Marie and von Gunten, Stephan

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2234-943X

Publisher:

Frontiers Research Foundation

Language:

English

Submitter:

Jana Berger

Date Deposited:

24 Apr 2018 14:07

Last Modified:

24 Apr 2018 14:07

Publisher DOI:

10.3389/fonc.2018.00068

PubMed ID:

29594046

Uncontrolled Keywords:

The Cancer Genome Atlas cancer immunotherapy gynecologic malignancies sialic acid binding immunoglobulin-like lectins sialyltransferases

BORIS DOI:

10.7892/boris.114542

URI:

https://boris.unibe.ch/id/eprint/114542

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