Greuter, Thomas; Franc, Yannick; Kaelin, Matthias; Schoepfer, Alain M; Schreiner, Philipp; Zeitz, Jonas; Scharl, Michael; Misselwitz, Benjamin; Straumann, Alex; Vavricka, Stephan R; Rogler, Gerhard; von Känel, Roland; Biedermann, Luc (2018). Low serum zinc levels predict presence of depression symptoms, but not overall disease outcome, regardless of ATG16L1 genotype in Crohn's disease patients. Therapeutic advances in gastroenterology, 11, 1756283X18757715. Sage 10.1177/1756283X18757715
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Background
Zinc deficiency (ZD) in Crohn's disease (CD) is considered a frequent finding and may exacerbate CD activity. ZD is associated with depression in non-CD patients. We aimed to assess the prevalence of ZD in CD patients in clinical remission, its association with mood disturbances and to analyze a potential impact on future disease course.
Methods
Zinc levels from CD patients in clinical remission at baseline and an uncomplicated disease course within the next 3 years ( = 47) were compared with those from patients developing complications ( = 50). Baseline symptoms of depression and anxiety were measured with the Hospital Anxiety and Depression scale.
Results
Mean zinc level in the 97 patients (40.4 ± 15.7 years, 44.3% males) was 18.0 ± 4.7 μmol/l. While no ZD (<11 μmol/l) was observed, we found low zinc levels (<15.1 μmol/l) in 28 patients (28.9%). Males had higher zinc levels compared with females (19.4 ± 5.7 16.8 ± 3.3, = 0.006). Patients with low zinc levels more often reported depression symptoms compared with patients with higher levels (27.3 9.4%, = 0.047). In a multivariate analysis, zinc levels were an independent negative predictor for depression symptoms [odds ratio (OR) 0.727, 95% confidence interval (CI) 0.532-0.993, = 0.045]. Zinc levels of patients with a complicated disease course were not different from those of patients without (17.7 ± 4.3 18.3 ± 5.1, n.s.). Baseline zinc levels did not predict disease outcome regardless of ATG16L1 genotype.
Conclusion
Low-normal zinc levels were an independent predictor for the presence of depression symptoms in CD patients. Zinc levels at baseline did not predict a complicated disease course, neither in CD patients overall, nor ATG16L1 carriers.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Forschungsbereich Mu50 > Forschungsgruppe Psychosomatik |
UniBE Contributor: |
von Känel, Roland |
ISSN: |
1756-283X |
Publisher: |
Sage |
Language: |
English |
Submitter: |
Stefanie Hetzenecker |
Date Deposited: |
26 Apr 2018 13:01 |
Last Modified: |
05 Dec 2022 15:12 |
Publisher DOI: |
10.1177/1756283X18757715 |
PubMed ID: |
29487628 |
Uncontrolled Keywords: |
ATG16L1 Crohn’s disease anxiety depression disease course single nucleotide polymorphism zinc |
BORIS DOI: |
10.7892/boris.114698 |
URI: |
https://boris.unibe.ch/id/eprint/114698 |