Periodic limb movements during sleep in stroke/TIA: Prevalence, course, and cardiovascular burden.

Manconi, Mauro; Fanfulla, Francesco; Ferri, Raffaele; Miano, Silvia; Haba-Rubio, Josè; Heinzer, Raphael; Horvath, Thomas; Proserpio, Paola; Young, Peter; Moschovitis, Giorgio; Seiler, Andrea Barbara; Cereda, Carlo; Nobili, Lino; Wiest, Roland; Ott, Sebastian Robert; Bassetti, Claudio (2018). Periodic limb movements during sleep in stroke/TIA: Prevalence, course, and cardiovascular burden. Neurology, 90(19), e1663-e1672. Lippincott Williams & Wilkins 10.1212/WNL.0000000000005471

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To define the prevalence, time course, and associated factors of periodic limb movements during sleep (PLMS) in patients with ischemic stroke or TIA.


Patients enrolled in the prospective Sleep-Disordered Breathing in Transient Ischemia Attack (TIA)/Ischemic Stroke and Continuous Positive Airway Pressure (CPAP) Treatment Efficacy (SAS-CARE) study underwent a double polysomnographic investigation in the acute and chronic phases after stroke/TIA, together with a MRI brain scan and a 24-hour blood pressure evaluation. The prevalence of PLMS in patients was compared with that in a matched sample of randomly selected healthy controls from the HypnoLaus cohort. One hundred sixty-nine recordings were performed in the acute phase and 191 after 3 months (210 recordings were obtained from the same 105 patients in both phases) and were compared to those of 162 controls.


The mean number of PLMS per hour and the percentage of participants with a PLMS index >10 and >15 per hour were similar between patients and controls. PLMS remained stable from the acute to the chronic phase after stroke. Factors positively associated with PLMS were age, body mass index, and history of hypertension. Blood pressure over 24 hours and the burden of cerebrovascular damage were similar between the groups with PLMS and without PLMS.


PLMS are equally frequent in patients with stroke/TIA and the general population. The absence of higher blood pressure values and of a greater vascular brain damage found in patients with PLMS compared to those without PLMS might be due to a greater use of antihypertensive medication among patients with PLMS, which corresponds to a higher prevalence of previous diagnosis of hypertension in patients with PLMS.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Pneumology
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic and Interventional Neuroradiology
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Manconi, Mauro, Miano, Silvia, Horvath, Thomas Nikolaus, Seiler, Andrea Barbara, Nobili, Lino, Wiest, Roland Gerhard Rudi, Ott, Sebastian Robert, Bassetti, Claudio L.A.


600 Technology > 610 Medicine & health




Lippincott Williams & Wilkins




Martin Zbinden

Date Deposited:

26 Apr 2018 14:47

Last Modified:

02 Mar 2023 23:30

Publisher DOI:


PubMed ID:


Additional Information:

Mauro Manconi and Francesco Fanfulla contributed equally to this work.




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