Erysimum cheiranthoides, an ecological research system with potential as a genetic and genomic model for studying cardiac glycoside biosynthesis

Züst, Tobias; Mirzaei, Mahdieh; Jander, Georg (2018). Erysimum cheiranthoides, an ecological research system with potential as a genetic and genomic model for studying cardiac glycoside biosynthesis. Phytochemistry reviews, 17(6), pp. 1239-1251. Springer 10.1007/s11101-018-9562-4

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At least twelve plant families contain species that synthesize cardiac glycosides as defense against herbivory. These inhibitors of animal Na+, K+-ATPases also have medical uses in treating congestive heart failure and other diseases. However, despite extensive ecological research and centuries of use in both traditional and modern medicine, the complete cardiac glycoside biosynthesis pathway has yet to be elucidated in any plant species. To a large extent, this research deficit results from the fact that cardiac glycosides are produced exclusively by non-model plant species such as Digitalis that have not been amenable to the development of mutagenesis, cloning, and genetic mapping approaches. Recent advances in genome sequencing, transcript profiling, plant transformation, transient expression assays, and plant metabolite analysis have provided new opportunities for the investigation and elucidation of cardiac glycoside biosynthesis pathways. The genetic tools that have been developed for Brassicaceae, in particular Arabidopsis thaliana, may be directly applicable to Erysimum, a Brassicaceae genus that characteristically produces cardiac glycosides as defensive metabolites. We propose that Erysimum cheiranthoides (wormseed wallflower), a rapid-cycling, self-pollinating species with a relatively small, diploid genome, would be a suitable model system to advance research on the biosynthesis of cardiac glycosides in plants.

Item Type:

Journal Article (Original Article)

Division/Institute:

08 Faculty of Science > Department of Biology > Institute of Plant Sciences (IPS) > Biotic Interactions
08 Faculty of Science > Department of Biology > Institute of Plant Sciences (IPS) > Plant Ecology
08 Faculty of Science > Department of Biology > Institute of Plant Sciences (IPS)

UniBE Contributor:

Züst, Tobias

Subjects:

500 Science > 580 Plants (Botany)

ISSN:

1568-7767

Publisher:

Springer

Language:

English

Submitter:

Peter Alfred von Ballmoos-Haas

Date Deposited:

07 May 2018 15:49

Last Modified:

26 Aug 2019 08:51

Publisher DOI:

10.1007/s11101-018-9562-4

Related URLs:

Uncontrolled Keywords:

Erysimum cheiranthoides; wallflower; cardiac glycoside; cardenolide; model system

BORIS DOI:

10.7892/boris.114835

URI:

https://boris.unibe.ch/id/eprint/114835

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