Association of Hepatitis C Virus—Specific CD8+ T Cells with Viral Clearance in Acute Hepatitis C

Grüner, Norbert H.; Gerlach, Tilman J.; Jung, Maria-Christina; Diepolder, Helmut M.; Schirren, Carl Albrecht; Schraut, Winfried W.; Hoffmann, Robert; Zachoval, Reinhart; Santantonio, Teresa; Cucchiarini, M.; Cerny, Andreas; Pape, Gerd R. (2000). Association of Hepatitis C Virus—Specific CD8+ T Cells with Viral Clearance in Acute Hepatitis C. Journal of infectious diseases, 181(5), pp. 1528-1536. The University of Chicago Press 10.1086/315450

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CD8+ T lymphocytes play a major role in antiviral immune defense. Their significance for acute hepatitis C is unclear. Our aim was to correlate the CD8+ T cell response with the outcome of infection. Eighteen patients with acute hepatitis C and 19 normal donors were studied. Hepatitis C virus (HCV)—specific CD8+ T cells were identified in the enzyme-linked immunospot assay by their interferon-γ (IFN-γ) production after specific stimulation. The highest numbers of IFN-γ—producing HCV-specific CD8+ T cells were found in patients with acute hepatitis C and a self-limited course of disease during the first 6 months after onset of disease, but these numbers dropped thereafter to undetectable levels. The differences in responsiveness between patients with self-limited disease versus patients with a chronic course were statistically significant (P < .001). Our data show that the number of IFN—γ-producing HCV-specific CD8+ T cells during the first 6 months after onset of disease is associated with eradication of the HCV infection.

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