Cytokine Profiles in Toxoplasmic and Viral Uveitis

Lahmar, Ibtissem; Abou-Bacar, Ahmed; Abdelrahman, Tamer; Guinard, Marie; Babba, Hamouda; Ben Yahia, Salim; Kairallah, Moncef; Speeg-Schatz, Claude; Bourcier, Tristan; Sauer, Arnaud; Villard, Odile; Pfaff, Alexander W.; Mousli, Marc; Garweg, Justus G.; Candolfi, Ermanno (2009). Cytokine Profiles in Toxoplasmic and Viral Uveitis. Journal of infectious diseases, 199(8), pp. 1239-1249. The University of Chicago Press 10.1086/597478

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Background: Uveitis is a major cause of visual impairment throughout the world. Analysis of cytokine profiles in aqueous humor specimens may provide insight into the physiopathological processes that underly retinal damage in this context

Methods: Using a multiplex assay, we determined the concentrations of 17 cytokines and chemokines in aqueous humor specimens obtained from patients with ocular toxoplasmosis or viral uveitis and compared these concentrations with those in specimens obtained from patients with noninfectious intermediate uveitis or cataract

Results: Five mediators (interleukin [IL]–8, monocyte chemoattractant protein–1, tumor necrosis factor–α, IL-4, and IL-10) were detected in >50% of patients in all groups. In contrast, IL-5 and IL-12 were specific for ocular toxoplasmosis, and granulocyte monocyte colony-stimulating factor and IL-1 were specific for viral uveitis; these mediators could present specific markers for diagnostic purposes. Interferon-γ, IL-6, and macrophage inflammatory protein-1β were common markers of ocular toxoplasmosis and viral uveitis. IL-17 was a common marker of ocular toxoplasmosis and intermediate uveitis

Conclusions: We found specific cytokine profiles for each type of uveitis, with large interindividual variations and no etiological or clinical correlations. Ocular cytokine mapping contributes to a better understanding of the physiopathology of specific forms of uveitis and provides guidance for new targeted treatment

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ophthalmology

UniBE Contributor:

Garweg, Justus

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0022-1899

Publisher:

The University of Chicago Press

Language:

English

Submitter:

Marceline Brodmann

Date Deposited:

15 Oct 2020 10:43

Last Modified:

15 Oct 2020 10:43

Publisher DOI:

10.1086/597478

BORIS DOI:

10.7892/boris.115004

URI:

https://boris.unibe.ch/id/eprint/115004

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