Lahmar, Ibtissem; Abou-Bacar, Ahmed; Abdelrahman, Tamer; Guinard, Marie; Babba, Hamouda; Ben Yahia, Salim; Kairallah, Moncef; Speeg-Schatz, Claude; Bourcier, Tristan; Sauer, Arnaud; Villard, Odile; Pfaff, Alexander W.; Mousli, Marc; Garweg, Justus G.; Candolfi, Ermanno (2009). Cytokine Profiles in Toxoplasmic and Viral Uveitis. Journal of infectious diseases, 199(8), pp. 1239-1249. The University of Chicago Press 10.1086/597478
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Background: Uveitis is a major cause of visual impairment throughout the world. Analysis of cytokine profiles in aqueous humor specimens may provide insight into the physiopathological processes that underly retinal damage in this context
Methods: Using a multiplex assay, we determined the concentrations of 17 cytokines and chemokines in aqueous humor specimens obtained from patients with ocular toxoplasmosis or viral uveitis and compared these concentrations with those in specimens obtained from patients with noninfectious intermediate uveitis or cataract
Results: Five mediators (interleukin [IL]–8, monocyte chemoattractant protein–1, tumor necrosis factor–α, IL-4, and IL-10) were detected in >50% of patients in all groups. In contrast, IL-5 and IL-12 were specific for ocular toxoplasmosis, and granulocyte monocyte colony-stimulating factor and IL-1 were specific for viral uveitis; these mediators could present specific markers for diagnostic purposes. Interferon-γ, IL-6, and macrophage inflammatory protein-1β were common markers of ocular toxoplasmosis and viral uveitis. IL-17 was a common marker of ocular toxoplasmosis and intermediate uveitis
Conclusions: We found specific cytokine profiles for each type of uveitis, with large interindividual variations and no etiological or clinical correlations. Ocular cytokine mapping contributes to a better understanding of the physiopathology of specific forms of uveitis and provides guidance for new targeted treatment
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ophthalmology |
UniBE Contributor: |
Garweg, Justus |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0022-1899 |
Publisher: |
The University of Chicago Press |
Language: |
English |
Submitter: |
Marceline Brodmann |
Date Deposited: |
15 Oct 2020 10:43 |
Last Modified: |
05 Dec 2022 15:12 |
Publisher DOI: |
10.1086/597478 |
BORIS DOI: |
10.7892/boris.115004 |
URI: |
https://boris.unibe.ch/id/eprint/115004 |
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