Comparative Studies of Fluoroquinolones in the Treatment of Urinary Tract Infections

Malinverni, R.; Glauser, M. P. (1988). Comparative Studies of Fluoroquinolones in the Treatment of Urinary Tract Infections. Reviews of infectious diseases, 10(Suppl. 1), S153-S163. The University of Chicago Press 10.1093/clinids/10.Supplement_1.S153

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The results of comparative trials of fluoroquinolones for the treatment of uncomplicated and complicated urinary tract infections (UTI) were reviewed. Severalrandomized, comparative trials showedthat in uncomplicatedUTI norfloxacin, ciprofloxacin, and ofloxacin wereat least as effectiveas trimethoprim-sulfamethoxazole (TMP-SMZ) and amoxicillinand usually more effectivethan nalidixicacid, pipemidic acid, and nitrofurantoin. Comparativetrials of single-dose regimens have, however, beenlimited. A few randomized, comparative trials have shown that in complicated UTI norfloxacin, ciprofloxacin, and ofloxacin wereat least as effectiveas amoxicillinand TMP-SMZand usually more effective than pipemidic acid. Moreover, preliminary results indicate that fluoroquinolones might be effective for the oral treatment of complicated UTI that are difficult to treat, especially those due to Pseudomonas aeruginosa. Comparative trials are neededto establish the value of fluoroquinolones for chronic bacterial prostatitis. There are no conclusivedata on fluoroquinolone treatment of UTI in patients with renal failure. Emergence of resistantpathogensduring therapywith fluoroquinolones has beeninfrequentbut might be more frequent in complicated UTI caused by P. aeruginosa.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Clinic of General Internal Medicine > Centre of Competence for General Internal Medicine

UniBE Contributor:

Malinverni, Raffaele

ISSN:

0162-0886

Publisher:

The University of Chicago Press

Language:

English

Submitter:

Marceline Brodmann

Date Deposited:

28 Oct 2020 17:15

Last Modified:

28 Oct 2020 17:21

Publisher DOI:

10.1093/clinids/10.Supplement_1.S153

BORIS DOI:

10.7892/boris.115071

URI:

https://boris.unibe.ch/id/eprint/115071

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