Immunization of Noncolonized Cystic Fibrosis Patients against Pseudomonas aeruginosa

Cryz, Stanley J.; Wedgwood, Joanna; Lang, Alois B.; Ruedeberg, Anna; Que, J. U.; Fürer, Emil; Schaad, Urs B. (1994). Immunization of Noncolonized Cystic Fibrosis Patients against Pseudomonas aeruginosa. Journal of infectious diseases, 169(5), pp. 1159-1162. The University of Chicago Press 10.1093/infdis/169.5.1159

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The long-term safety and immunogenicity of a polyvalent Pseudomonas aeruginosa conjugate vaccine was evaluated in 30 noncolonized cystic fibrosis patients. Four doses were administered over 3 years, and patients were followed for a mean of 38 months. No acute or long-term adverse effects were noted. Immunization engendered a significant antibody response to all vaccine components. A decline in titers during year 3 of observation was associated with a marked rise in the isolation of P. aeruginosa. This organism was isolated repeatedly from the respiratory tract of 4 patients and only once from 7 patients. The remaining patients were repeatedly culture-negative. Only 1 patient showed clinical deterioration associated with multiple isolations of P. aeruginosa.

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