Induction of Prostaglandin Release from Macrophages by Bacterial Endotoxin

Offenbacher, S.; Salvi, G. E. (1999). Induction of Prostaglandin Release from Macrophages by Bacterial Endotoxin. Clinical infectious diseases, 28(3), pp. 505-513. The University of Chicago Press 10.1086/515177

[img]
Preview
Text
28-3-505.pdf - Published Version
Available under License Publisher holds Copyright.

Download (155kB) | Preview

This review summarizes the role of the monocytic responses to lipopolysaccharide as it relates to periodontal disease severity. Data are presented which illustrate that the levels of prostaglandin E2 (PGE2) secreted by systemic peripheral blood monocytes in culture, in the presence of bacterial endotoxins, are highly correlated with the levels observed in the gingival crevicular fluid. Furthermore, the different periodontal diagnostic categories have varying levels of monocytic and crevicular fluid PGE2, in juxtaposition with clinical disease severity. These data are consistent with the concept that there is close synchrony between the systemic responsiveness of peripheral blood monocytes with regard to prostanoid synthesis and the local levels of mediator present within the gingival crevice.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > School of Dental Medicine > Department of Periodontology

UniBE Contributor:

Salvi, Giovanni Edoardo

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1058-4838

Publisher:

The University of Chicago Press

Language:

English

Submitter:

Marceline Brodmann

Date Deposited:

10 Nov 2020 11:47

Last Modified:

10 Nov 2020 11:47

Publisher DOI:

10.1086/515177

BORIS DOI:

10.7892/boris.115238

URI:

https://boris.unibe.ch/id/eprint/115238

Actions (login required)

Edit item Edit item
Provide Feedback