Schmucker, Douglas L.; Wang, Rose K.; Snyder, David; Strobel, Henry; Marti, Ulrich (1991). Caloric Restriction Affects Liver Microsomal Monooxygenases Differentially in Aging Male Rats. Journal of gerontology, 46(1), B23-B27. The Gerontological Society of America 10.1093/geronj/46.1.B23
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Caloric restriction (CR) extends life span and retards the onset of physiological changes and pathologies associated with aging, but the underlying mechanisms remain unresolved. This study demonstrates that CR postpones the documented age-related declines in and/or enhances the activity and microsomal concentrations of several liver monooxygenases in male rats, i.e., NADPH cytochrome P-450 reductase, total cytochromes P-450. However, the relative concentration of cytochrome P-450b+c did not exhibit statistically significant changes, whereas another isozyme, the male specific P-450h, declined significantly in both ad libitum-fed and CR rats as a function of increasing age. While CR appears to retard age-associated changes in certain liver enzymes, this effect is by no means universal. The hepatic monooxygenases constitute a well-characterized enzyme system in which to examine the perturbation of the aging process by CR.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases > Laboratory for Clinical Pharmacology |
ISSN: |
0022-1422 |
Publisher: |
The Gerontological Society of America |
Language: |
English |
Submitter: |
Marceline Brodmann |
Date Deposited: |
23 Sep 2020 10:20 |
Last Modified: |
23 Sep 2020 10:20 |
Publisher DOI: |
10.1093/geronj/46.1.B23 |
BORIS DOI: |
10.7892/boris.115398 |
URI: |
https://boris.unibe.ch/id/eprint/115398 |
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