Cytoskeleton-associated antigens from African trypanosomes are recognized by self-reactive antibodies of uninfected mice

Müller, N.; Imboden, M.; Detmer, E.; Mansfield, J. M.; Seebeck, T. (1993). Cytoskeleton-associated antigens from African trypanosomes are recognized by self-reactive antibodies of uninfected mice. Parasitology, 107(4), pp. 411-417. Cambridge University Press 10.1017/S0031182000067767

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Serum from uninfected mice of different strains, as well as from germ-free animals, contains antibodies which react specifically with at least two trypanosomal proteins, I/6 and MARP1. These antibody populations are highly specific for the respective proteins, are of similar affinity as hyperimmune antibodies, and consist of IgM as well as IgG isotypes. Hyperimmune antibody raised against the cross-reacting trypanosomal protein I/6 detects a 60 kDa protein in mouse 3T6 cells, which is a component of the fibroblast cytoskeleton.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Parasitology
08 Faculty of Science > Department of Biology > Institute of Cell Biology

UniBE Contributor:

Seebeck, Thomas

Subjects:

500 Science > 570 Life sciences; biology

ISSN:

0031-1820

Publisher:

Cambridge University Press

Language:

English

Submitter:

Marceline Brodmann

Date Deposited:

16 Jul 2020 09:43

Last Modified:

24 Jul 2020 18:51

Publisher DOI:

10.1017/S0031182000067767

PubMed ID:

7506406

BORIS DOI:

10.7892/boris.115441

URI:

https://boris.unibe.ch/id/eprint/115441

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