Osseointegration and biocompatibility of different metal implants-a comparative experimental investigation in sheep

Plecko, Michael; Sievert, Christine; Andermatt, Daniel; Frigg, Robert; Kronen, Peter; Klein, Karina; Stübinger, Stefan; Nuss, Katja; Bürki, Alexander; Ferguson, Stephen; Stoeckle, Ulrich; von Rechenberg, Brigitte (2012). Osseointegration and biocompatibility of different metal implants-a comparative experimental investigation in sheep. BMC musculoskeletal disorders, 13(1), p. 32. London: BioMed Central 10.1186/1471-2474-13-32

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Background In the present study, 4 different metallic implant materials, either partly coated or polished, were tested for their osseointegration and biocompatibility in a pelvic implantation model in sheep. Methods Materials to be evaluated were: Cobalt-Chrome (CC), Cobalt-Chrome/Titanium coating (CCTC), Cobalt-Chrome/Zirconium/Titanium coating (CCZTC), Pure Titanium Standard (PTST), Steel, TAN Standard (TANST) and TAN new finish (TANNEW). Surgery was performed on 7 sheep, with 18 implants per sheep, for a total of 63 implants. After 8 weeks, the specimens were harvested and evaluated macroscopically, radiologically, biomechanically (removal torque), histomorphometrically and histologically. Results Cobalt-Chrome screws showed significantly (p = 0.031) lower removal torque values than pure titanium screws and also a tendency towards lower values compared to the other materials, except for steel. Steel screws showed no significant differences, in comparison to cobalt-chrome and TANST, however also a trend towards lower torque values than the remaining materials. The results of the fluorescence sections agreed with those of the biomechanical test. Histomorphometrically, there were no significant differences of bone area between the groups. The BIC (bone-to-implant-contact), used for the assessment of the osseointegration, was significantly lower for cobalt-chrome, compared to steel (p = 0.001). Steel again showed a lower ratio (p = 0.0001) compared to the other materials. Conclusion This study demonstrated that cobalt-chrome and steel show less osseointegration than the other metals and metal-alloys. However, osseointegration of cobalt-chrome was improved by zirconium and/or titanium based coatings (CCTC, TANST, TAN, TANNEW) being similar as pure titanium in their osseointegrative behavior.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute for Surgical Technology & Biomechanics ISTB

UniBE Contributor:

Bürki, Alexander

ISSN:

1471-2474

Publisher:

BioMed Central

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:30

Last Modified:

09 Dec 2014 04:26

Publisher DOI:

10.1186/1471-2474-13-32

Web of Science ID:

000302356800001

BORIS DOI:

10.7892/boris.11547

URI:

https://boris.unibe.ch/id/eprint/11547 (FactScience: 217749)

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