Hyperlactatemia and Antiretroviral Therapy: The Swiss HIV Cohort Study

Boubaker, K.; Flepp, M.; Sudre, P.; Furrer, Hansjakob; Haensel, A.; Hirschel, B.; Boggian, K.; Chave, J.-P.; Bernasconi, E.; Egger, M.; Opravil, M.; Rickenbach, M.; Francioli, P.; Telenti, A. (2001). Hyperlactatemia and Antiretroviral Therapy: The Swiss HIV Cohort Study. Clinical infectious diseases, 33(11), pp. 1931-1937. The University of Chicago Press 10.1086/324353

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The prevalence, clinical presentation, and risk factors for hyperlactatemia among patients receiving antiretroviral therapy was determined during a 1-month period for patients in the Swiss HIV Cohort Study. Overall, 73 (8.3%) of 880 patients presented an increase in serum lactate of >1.1 times the upper normal limit (UNL). For 9 patients (1%), lactate elevation was moderate or severe (>2.2 times the UNL). Patients who presented with hyperlactatemia were more likely to be receiving stavudine with or without didanosine (odds ratio, 2.7; 95% confidence interval, 1.5–4.8), as compared with patients who received zidovudine-based regimens. The risk increased with increasing time receiving stavudine with or without didanosine. The association between hyperlactatemia and stavudine with or without didanosine was not biased by these medications being more recently available and, therefore, being given preferentially to patients who had prolonged use of nucleoside analog reverse-transcriptase inhibitors. Hyperlactatemia was associated with lipoatrophy, hyperlipidemia, and hyperglycemia. Age, sex, or stage of infection with human immunodeficiency virus were not predictive of hyperlactatemia. Determination of lactate levels may prove useful in the screening for mitochondrial toxicity.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Infectiology

UniBE Contributor:

Furrer, Hansjakob

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1058-4838

Publisher:

The University of Chicago Press

Language:

English

Submitter:

Marceline Brodmann

Date Deposited:

17 Nov 2020 09:05

Last Modified:

17 Nov 2020 09:05

Publisher DOI:

10.1086/324353

BORIS DOI:

10.7892/boris.115537

URI:

https://boris.unibe.ch/id/eprint/115537

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