Varicella-Zoster Virus Is Strongly Associated with Atypical Necrotizing Herpetic Retinopathies

Garweg, J.; Böhnke, M. (1997). Varicella-Zoster Virus Is Strongly Associated with Atypical Necrotizing Herpetic Retinopathies. Clinical infectious diseases, 24(4), pp. 603-608. The University of Chicago Press 10.1093/clind/24.4.603

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Aqueous humor samples from nine patients with atypical necrotizing retinopathies of suspected viral origin, six with acute retinal necrosis syndrome (ARN), and 17 with active cytomegalovirus (CMV) retinitis underwent amplification for viral DNA of herpes simplex virus type 1 (HSV-1), varicella-zoster virus (VZV), and human CMV. VZV DNA was detected in seven of the nine aqueous humor samples from patients with atypical necrotizing retinopathies of suspected viral origin and in four of the six samples from individuals with ARN; of the two other samples from patients with ARNS, no viral DNA was found in one, and both CMV DNA and HSV-1 DNA, but not VZV DNA, were detected in one (this patient presented with bilateral ARNS 2 months after being successfully treated for CMV retinitis). Thus, VZV is likely to be the main pathogen of atypical necrotizing herpetic retinopathies. DNA amplification may be used to establish an early, sensitive, and reliable diagnosis of any form of necrotizing retinopathy in 80% of cases, irrespective of viral etiology.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ophthalmology

UniBE Contributor:

Garweg, Justus

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1058-4838

Publisher:

The University of Chicago Press

Language:

English

Submitter:

Marceline Brodmann

Date Deposited:

10 Nov 2020 13:39

Last Modified:

10 Nov 2020 13:39

Publisher DOI:

10.1093/clind/24.4.603

BORIS DOI:

10.7892/boris.115541

URI:

https://boris.unibe.ch/id/eprint/115541

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