Pulmonary Arterial Hypertension Related to HIV Infection: Improved Hemodynamics and Survival Associated with Antiretroviral Therapy

Zuber, Jean-Philippe; Calmy, Alexandra; Evison, John M.; Hasse, Barbara; Schiffer, Veronique; Wagels, Thomas; Nuesch, Reto; Magenta, Lorenzo; Ledergerber, Bruno; Jenni, Rolf; Speich, Rudolf; Opravil, Milos (2004). Pulmonary Arterial Hypertension Related to HIV Infection: Improved Hemodynamics and Survival Associated with Antiretroviral Therapy. Clinical infectious diseases, 38(8), pp. 1178-1185. The University of Chicago Press 10.1086/383037

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This study aimed to assess the long-term course of pulmonary arterial hypertension related to infection with human immunodeficiency virus (PAHRH) and the influence of antiretroviral therapy (ART) on its characteristics. We retrospectively analyzed all 47 patients in the Swiss HIV Cohort Study in whom PAHRH was diagnosed. Among 35 patients who underwent follow-up Doppler echocardiography, the right ventricular systolic pressure over right atrial pressure gradient increased by a median of 25 mm Hg in 9 patients who had not received ART, decreased by a median of 3 mm Hg in 12 patients who had received nucleoside analogs, and decreased by a median of 21 mm Hg in 14 patients who had received highly active ART (HAART) (P < .005). Among all 47 patients, median duration of survival after PAHRH diagnosis was 2.7 years. HAART significantly decreased mortality due to PAHRH as well as other causes. This study suggests a beneficial effect of combination ART in patients with PAHRH.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Infectiology

UniBE Contributor:

Evison, John Marc

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1058-4838

Publisher:

The University of Chicago Press

Language:

English

Submitter:

Marceline Brodmann

Date Deposited:

17 Nov 2020 09:30

Last Modified:

17 Nov 2020 09:30

Publisher DOI:

10.1086/383037

BORIS DOI:

10.7892/boris.115550

URI:

https://boris.unibe.ch/id/eprint/115550

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