Cerebral blood flow identifies responders to transcranial magnetic stimulation in auditory verbal hallucinations

Homan, P; Kindler, J; Hauf, M; Hubl, D; Dierks, T (2012). Cerebral blood flow identifies responders to transcranial magnetic stimulation in auditory verbal hallucinations. Translational psychiatry, 2, e189. London: Nature Publishing Group 10.1038/tp.2012.114

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Auditory hallucinations comprise a critical domain of psychopathology in schizophrenia. Repetitive transcranial magnetic stimulation (TMS) has shown promise as an intervention with both positive and negative reports. The aim of this study was to test resting-brain perfusion before treatment as a possible biological marker of response to repetitive TMS. Twenty-four medicated patients underwent resting-brain perfusion magnetic resonance imaging with arterial spin labeling (ASL) before 10 days of repetitive TMS treatment. Response was defined as a reduction in the hallucination change scale of at least 50%. Responders (n=9) were robustly differentiated from nonresponders (n=15) to repetitive TMS by the higher regional cerebral blood flow (CBF) in the left superior temporal gyrus (STG) (P<0.05, corrected) before treatment. Resting-brain perfusion in the left STG predicted the response to repetitive TMS in this study sample, suggesting this parameter as a possible bio-marker of response in patients with schizophrenia and auditory hallucinations. Being noninvasive and relatively easy to use, resting perfusion measurement before treatment might be a clinically relevant way to identify possible responders and nonresponders to repetitive TMS.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic and Interventional Neuroradiology

UniBE Contributor:

Hauf, Martinus




Nature Publishing Group




Factscience Import

Date Deposited:

04 Oct 2013 14:30

Last Modified:

17 Mar 2015 21:16

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PubMed ID:


Web of Science ID:



https://boris.unibe.ch/id/eprint/11572 (FactScience: 217774)

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