Bleiber, Gabriela; May, Margaret; Suarez, Carlos; Martinez, Raquel; Marzolini, Catia; Egger, Matthias; Telenti, Amalio (2004). MDR1 Genetic Polymorphism Does Not Modify either Cell Permissiveness to HIV-1 or Disease Progression before Treatment. Journal of infectious diseases, 189(4), pp. 583-586. The University of Chicago Press 10.1086/380134
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Nonphysiological overexpression of the ABC transporter Pglycoprotein (P-gp), which is encoded by MDR1, has been associated with reduced susceptibility to human immunodeficiency virus (HIV) type 1 infection in vitro. We analyzed (1) the expression and genotype of MDR1 and their relationship to HIV-1 permissiveness of CD4+ T cells from 128 healthy blood donors and (2) the role that alleles of MDR1 exons 21 and 26 play in modifying disease progression in 411 HIV-1-infected individuals. Differences in physiological levels of MDR1 expression did not modify HIV-1 infection in vitro, nor did MDR1 alleles and haplotypes significantly influence either permissiveness to infection in vitro or disease progression in vivo before the initiation of treatment.
Item Type: |
Journal Article (Further Contribution) |
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Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM) |
UniBE Contributor: |
Egger, Matthias |
Subjects: |
600 Technology > 610 Medicine & health 300 Social sciences, sociology & anthropology > 360 Social problems & social services |
ISSN: |
0022-1899 |
Publisher: |
The University of Chicago Press |
Language: |
English |
Submitter: |
Marceline Brodmann |
Date Deposited: |
08 Oct 2020 10:16 |
Last Modified: |
05 Dec 2022 15:13 |
Publisher DOI: |
10.1086/380134 |
BORIS DOI: |
10.7892/boris.115825 |
URI: |
https://boris.unibe.ch/id/eprint/115825 |
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