Pfister, Marc; Jakob, Stephan M.; Marti, Hans-Peter; Frey, Felix J.; Gugger, Matthias (1999). Ambulatory nocturnal oximetry and sleep questionnaire-based findings in 38 patients with end-stage renal disease. Nephrology, dialysis, transplantation, 14(6), pp. 1496-1502. Oxford University Press 10.1093/ndt/14.6.1496
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Background: Patients with end-stage renal diseases (ESRD) have an increased risk of sleep-disordered breathing. With regard to this disorder, controversy persists about prevalence, cost-effective assessment and socio-economical relevance.
Methods: Therefore, we performed, for the first time, overnight ambulatory oximetry in combination with a sleep questionnaire in 38 unselected patients with ESRD and 37 healthy controls. An oxygen desaturation index (ODI) >15, defined as >15 falls in oxygen saturation of > or =4% per h, was observed more frequently in ESRD patients than in healthy controls (47 vs. 3%, P<0.001).
Results: In general, the results derived from the assessment of the Epworth Sleepiness Scale (ESS) as well as those from the visual analogue scale (VAS) did not reflect the ODI values of the respective patient population. Interestingly, 88% of ESRD patients with the questionnaire finding 'excessively loud snoring' had an ODI of >15 as compared with 13% without this complaint (P<0.05). Furthermore, 77% of ESRD patients with a systolic blood pressure >140 mm Hg and a body mass index (BMI) >25, had an ODI of >15. The percentage of ESRD patients with a professional activity was higher in the absence of sleep-disordered breathing (63 vs. 21%, P<0.05).
Conclusion: 'Excessively loud snoring' and a BMI >25 combined with hypertension are risk factors for sleep-disordered breathing in ESRD patients. Nocturnal oxygen desaturations are assessed efficiently by ambulatory oximetry and correlate with relevant biological and socio-economical parameters in ESRD patients.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Nephrology and Hypertension 04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Pneumology |
UniBE Contributor: |
Marti, Hans-Peter, Frey, Felix (B), Gugger, Matthias |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0931-0509 |
Publisher: |
Oxford University Press |
Language: |
English |
Submitter: |
Marceline Brodmann |
Date Deposited: |
01 Oct 2020 08:44 |
Last Modified: |
29 Mar 2023 23:36 |
Publisher DOI: |
10.1093/ndt/14.6.1496 |
BORIS DOI: |
10.7892/boris.115827 |
URI: |
https://boris.unibe.ch/id/eprint/115827 |
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