Oral Immunization of Wildlife Against Rabies: Concept and First Field Experiments

Wandeler, A. I.; Capt, S.; Kappeler, A.; Hauser, R. (1988). Oral Immunization of Wildlife Against Rabies: Concept and First Field Experiments. Reviews of infectious diseases, 10(Suppl. 4), S649-S653. The University of Chicago Press 10.1093/clinids/10.Supplement_4.S649

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The possibility of immunizing carnivores against rabies with live attenuated vaccine administered by the oral route was raised by North American scientists in the 1960s. Subsequently, several American and European teams tested different vaccine strains in the laboratory for efficacy and safety and studied vaccine stabilization, vaccine delivery systems, baIt acceptance by wl1d ammals, and bait distribution schemes. The first field trial of a cloned SAD (Street Alabama Dufferin) strain in baits designed to immunize foxes orally ~as conducted in an Alpine valley in Switzerland in 1978. A population containing ∼60% immune foxes at the valley entrance stopped the spread of the disease into untreated upper parts of the valley. T~e strategic use of oral vaccination of foxes in additional regions of SWItzerland resulted m freedom from the zoonosis in four-fifths of the country.

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