Risk factors for low urinary citrate in calcium nephrolithiasis: low vegetable fibre intake and low urine volume to be added to the list

Hess, B.; Michel, R.; Takkinen, R.; Ackermann, D.; Jaeger, Ph. (1994). Risk factors for low urinary citrate in calcium nephrolithiasis: low vegetable fibre intake and low urine volume to be added to the list. Nephrology, dialysis, transplantation, 9(6), pp. 642-649. Oxford University Press 10.1093/ndt/9.6.642

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isk factors for low urinary citrate excretion were assessed in 34 consecutive male recurrent idiopathic calcium stone formers (RCSF) who collected two 24-h urines while on free-choice diet. Overt hypocitraturia (hypo-cit) was defined as UCit×V<1.70 mmol/day, and ‘low’ citraturia (low-cit) as UCit×V between 1.70 and 2.11 mmol/day. Twenty-three RCSF had normocitraturia (normo-cit), six low-cit and five hypo-cit. UCit×V positively correlated with urine volume (VOLUME, r=0.44, P=0.009), vegetable fibre intake (fibers, r=0.46, P=0.009) and GI-alkali absorption (alkali, r=0.47, P=0.006), and volume, fibres and alkali tended to be lower among RCSF with low-/hypo-cit. A 3-day NH4Cl loading test (0.95 mEq/kg BW daily in 3 doses) was performed in RCSF as well as in 14 age-matched healthy male controls (C). On a plot of urine pH versus serum bicarbonate, 10 of 11 RCSF with low-/hypo-cit, but only six of 23 with normo-cit (P=0.0004) fell off the normal range, indicating incomplete RTA. Two or more risk factors simultaneously occurred in only four of 23 RCSF with normo-cit, but in eight of 11 with low-/hypo-cit (P= 0.002). In conclusion, incomplete RTA is the most prevalent risk factor for low-/hypo-cit in RCSF, and decreases in vegetable fibres and urine volume emerge as two new risk factors for low urinary CIT.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Clinic of General Internal Medicine
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Urology

UniBE Contributor:

Ackermann, Daniel Konrad

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0931-0509

Publisher:

Oxford University Press

Language:

English

Submitter:

Marceline Brodmann

Date Deposited:

07 Sep 2020 12:15

Last Modified:

07 Sep 2020 13:39

Publisher DOI:

10.1093/ndt/9.6.642

BORIS DOI:

10.7892/boris.115903

URI:

https://boris.unibe.ch/id/eprint/115903

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