Imboden, M.; Müller, N.; Hemphill, A.; Mattioli, R.; Seebeck, T. (1995). Repetitive proteins from the flagellar cytoskeleton of African trypanosomes are diagnostically useful antigens. Parasitology, 110(3), pp. 249-258. Cambridge University Press 10.1017/S0031182000080835
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Trypanosome infection of mammalian hosts leads, within days, to a strong early response against a small, distinct number of parasite proteins. One of these proteins is the variable surface glycoprotein (VSG). Most of the others are apparently non-variable, intracellular trypanosome proteins. Two of these antigens I2 and I17 are now characterized at the molecular level. Both exhibit a highly repetitive amino acid sequence organization, but they show no sequence similarity either to each other or to any other proteins known to date. Preliminary serological analyses indicate that both allow the early, sensitive and specific detection of infections with different species of trypanosomatids, making them interesting candidates for the development of diagnostic tools for trypanosomiasis detection.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
08 Faculty of Science > Department of Biology > Institute of Cell Biology 05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Parasitology |
UniBE Contributor: |
Müller, Norbert, Hemphill, Andrew, Seebeck, Thomas |
Subjects: |
500 Science > 570 Life sciences; biology 600 Technology > 630 Agriculture |
ISSN: |
0031-1820 |
Publisher: |
Cambridge University Press |
Language: |
English |
Submitter: |
Marceline Brodmann |
Date Deposited: |
16 Jul 2020 09:04 |
Last Modified: |
05 Dec 2022 15:13 |
Publisher DOI: |
10.1017/S0031182000080835 |
PubMed ID: |
7724233 |
BORIS DOI: |
10.7892/boris.115917 |
URI: |
https://boris.unibe.ch/id/eprint/115917 |
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