Repetitive proteins from the flagellar cytoskeleton of African trypanosomes are diagnostically useful antigens

Imboden, M.; Müller, N.; Hemphill, A.; Mattioli, R.; Seebeck, T. (1995). Repetitive proteins from the flagellar cytoskeleton of African trypanosomes are diagnostically useful antigens. Parasitology, 110(3), pp. 249-258. Cambridge University Press 10.1017/S0031182000080835

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Trypanosome infection of mammalian hosts leads, within days, to a strong early response against a small, distinct number of parasite proteins. One of these proteins is the variable surface glycoprotein (VSG). Most of the others are apparently non-variable, intracellular trypanosome proteins. Two of these antigens I2 and I17 are now characterized at the molecular level. Both exhibit a highly repetitive amino acid sequence organization, but they show no sequence similarity either to each other or to any other proteins known to date. Preliminary serological analyses indicate that both allow the early, sensitive and specific detection of infections with different species of trypanosomatids, making them interesting candidates for the development of diagnostic tools for trypanosomiasis detection.

Item Type:

Journal Article (Original Article)

Division/Institute:

08 Faculty of Science > Department of Biology > Institute of Cell Biology
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Parasitology

UniBE Contributor:

Müller, Norbert; Hemphill, Andrew and Seebeck, Thomas

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 630 Agriculture

ISSN:

0031-1820

Publisher:

Cambridge University Press

Language:

English

Submitter:

Marceline Brodmann

Date Deposited:

16 Jul 2020 09:04

Last Modified:

27 Jul 2020 22:20

Publisher DOI:

10.1017/S0031182000080835

PubMed ID:

7724233

BORIS DOI:

10.7892/boris.115917

URI:

https://boris.unibe.ch/id/eprint/115917

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