An Investigation of the Steady-State Pharmacokinetics of Oral Valacyclovir in Immunocompromised Children

Nadal, David; Leverger, Guy; Sokal, Etienne M.; Floret, Daniel; Perel, Yves; Leibundgut, Kurt; Weller, Stephen (2002). An Investigation of the Steady-State Pharmacokinetics of Oral Valacyclovir in Immunocompromised Children. Journal of infectious diseases, 186(Suppl 1), S123-S130. The University of Chicago Press 10.1086/342968

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Valacyclovir was administered to 28 immunocompromised children (ages 5–12 years) to obtain preliminary pharmacokinetic and safety information. Patients were randomized to valacyclovir regimens of 250 mg (9.4–13.3 mg/kg) or 500 mg (13.9–27.0 mg/kg) twice daily or 500 mg (13.2–21.7 mg/kg) 3 times a day. Acyclovir pharmacokinetics were evaluated at steady state. Valacyclovir was rapidly absorbed and converted to acyclovir. Mean (±SD) acyclovir peak concentrations from 250 mg and 500 mg valacyclovir were 4.11±1.41 and 5.19±1.96 μg/mL, respectively. Corresponding single dose area-under-curve values were 12.14±6.60 and 14.49±4.69h×μg/mL. By using historical data for intravenous acyclovir as reference, the overall estimate of acyclovir bioavailability from valacyclovir was 48%, 2- to 4-fold greater than for oral acyclovir. In general, adverse events were not attributable to valacyclovir and were consistent with disease-related expectations and concomitant therapies. Dosage options for using valacyclovir in children are discussed.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine

UniBE Contributor:

Leibundgut, Kurt

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0022-1899

Publisher:

The University of Chicago Press

Language:

English

Submitter:

Marceline Brodmann

Date Deposited:

08 Oct 2020 13:32

Last Modified:

08 Oct 2020 13:32

Publisher DOI:

10.1086/342968

BORIS DOI:

10.7892/boris.116025

URI:

https://boris.unibe.ch/id/eprint/116025

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