Novel Approaches to the Identification of Streptococcus pneumoniae as the Cause of Community-Acquired Pneumonia

Klugman, Keith P.; Madhi, Shabir A.; Albrich, Werner C. (2008). Novel Approaches to the Identification of Streptococcus pneumoniae as the Cause of Community-Acquired Pneumonia. Clinical infectious diseases, 47(S3), S202-S206. The University of Chicago Press 10.1086/591405

[img]
Preview
Text
47-Supplement_3-S202.pdf - Published Version
Available under License Publisher holds Copyright.

Download (223kB) | Preview

Current diagnostic tests lack sensitivity for the identification of the bacterial etiology of pneumonia. Attempts during the past 2 decades to improve sensitivity of detection of bacterial constituents in blood by use of antibody-antigen complexes and polymerase chain reaction have been disappointing. Recent data using pneumococcal conjugate vaccines as probes suggest that increased levels of both C-reactive protein and procalcitonin may be useful adjuncts to chest radiographs in the selection of patients with presumed bacterial pneumonia for inclusion in clinical trials. Among pneumococcal diagnostics currently under investigation, quantitative real-time polymerase chain reaction of respiratory secretions, as well as urinary antigen detection and pneumococcal surface adhesin A serological analysis for adults, are candidates for use in future clinical trials of antibiotics.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Infectiology

UniBE Contributor:

Albrich, Werner

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1058-4838

Publisher:

The University of Chicago Press

Language:

English

Submitter:

Marceline Brodmann

Date Deposited:

29 Oct 2020 14:46

Last Modified:

29 Oct 2020 14:46

Publisher DOI:

10.1086/591405

BORIS DOI:

10.7892/boris.116103

URI:

https://boris.unibe.ch/id/eprint/116103

Actions (login required)

Edit item Edit item
Provide Feedback