Foscarnet Decreases Human Immunodeficiency Virus RNA

Kaiser, Laurent; Perrin, Luc; Hirschel, Bernard; Furrer, Hansjakob; Von Overbeck, Jan; Olmari, Maya; Yerly, Sabine (1995). Foscarnet Decreases Human Immunodeficiency Virus RNA. Journal of infectious diseases, 172(1), pp. 225-227. The University of Chicago Press 10.1093/infdis/172.1.225

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Foscarnet inhibits human immunodeficiency virus (HIV) replication in vitro and decreases p24 antigenemia in patients with cytomegalovirus (CMV) retinitis. To evaluate the effect of foscarnet on HIV replication, HIV RNA was quantitated in 17 patients before and during foscarnet therapy. Fifteen patients had CMV retinitis, 1 had CMV encephalitis, and 1 had intractable zoster. A decrease in HIV RNA was observed in 16 of 17 patients. Before the introduction of foscarnet, mean HIV RNA was 5.82 ± 0.24 log RNA/mL and, after a median of 13 days of therapy, mean HIV RNA was 5.30 ± 0.27 log RNA/mL (P < .001). Among patients with detectable p24 antigen at baseline, a significant decrease was observed (P = .017). This decrease in HIV RNA demonstrates that foscarnet is a potent antiretroviral drug.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Infectiology

UniBE Contributor:

Furrer, Hansjakob

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0022-1899

Publisher:

The University of Chicago Press

Language:

English

Submitter:

Marceline Brodmann

Date Deposited:

15 Oct 2020 09:43

Last Modified:

05 Dec 2022 15:13

Publisher DOI:

10.1093/infdis/172.1.225

BORIS DOI:

10.7892/boris.116121

URI:

https://boris.unibe.ch/id/eprint/116121

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