Copper homeostasis in Enterococcus hirae

Solioz, Marc; Stoyanov, Jivko V. (2003). Copper homeostasis in Enterococcus hirae. FEMS microbiology reviews, 27(2-3), pp. 183-195. Elsevier 10.1016/S0168-6445(03)00053-6

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Copper is an essential component of life because of its convenient redox potential of 200–800 mV when bound to protein. Extensive insight into copper homeostasis has only emerged in the last decade and Enterococcus hirae has served as a paradigm for many aspects of the process. The cop operon of E. hirae regulates copper uptake, availability, and export. It consists of four genes that encode a repressor, CopY, a copper chaperone, CopZ, and two CPx-type copper ATPases, CopA and CopB. Most of these components have been conserved across the three evolutionary kingdoms. The four Cop proteins have been studied in vivo as well as in vitro and their function is understood in some detail.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Clinical Pharmacology and Visceral Research [discontinued]

UniBE Contributor:

Solioz, Marc and Stoyanov, Jivko

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0168-6445

Publisher:

Elsevier

Language:

English

Submitter:

Marceline Brodmann

Date Deposited:

16 Nov 2020 14:39

Last Modified:

13 Mar 2021 23:58

Publisher DOI:

10.1016/S0168-6445(03)00053-6

BORIS DOI:

10.7892/boris.116133

URI:

https://boris.unibe.ch/id/eprint/116133

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