Yizhar, Ofer; Adamantidis, Antoine Roger (2018). Cell Type-Specific Targeting Strategies for Optogenetics. In: Stroh, Albrecht (ed.) Optogenetics: A Roadmap. Neuromethods: Vol. 133 (pp. 25-42). New York, NY: Humana Press 10.1007/978-1-4939-7417-7_2
Full text not available from this repository.Abstract View references (89)
Optogenetic techniques allow versatile, cell type-specific light-based control of cellular activity in diverse set of cells, circuits, and brain structures. Optogenetic actuators are genetically encoded light-sensitive membrane proteins that can be selectively introduced into cellular circuits in the living brain using a variety of genetic approaches. Gene targeting approaches used in optogenetic studies vary greatly in their specificity, their spatial coverage, the level of transgene expression and their potential adverse effects on neuronal cell health. Here, we describe the major gene targeting approaches utilized in optogenetics and provide a simple set of guidelines through which these approaches can be evaluated when designing an in vitro or in vivo optogenetic study. © Springer Science+Business Media LLC 2018.
Item Type: |
Book Section (Book Chapter) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology |
UniBE Contributor: |
Adamantidis, Antoine Roger |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1940-6045 |
ISBN: |
978-1-4939-7415-3 |
Series: |
Neuromethods |
Publisher: |
Humana Press |
Language: |
English |
Submitter: |
Stefanie Hetzenecker |
Date Deposited: |
09 May 2018 12:49 |
Last Modified: |
05 Dec 2022 15:13 |
Publisher DOI: |
10.1007/978-1-4939-7417-7_2 |
URI: |
https://boris.unibe.ch/id/eprint/116238 |
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