CD161 Defines a Functionally Distinct Subset of Pro-Inflammatory Natural Killer Cells.

Kurioka, Ayako; Cosgrove, Cormac; Simoni, Yannick; van Wilgenburg, Bonnie; Geremia, Alessandra; Björkander, Sophia; Sverremark-Ekström, Eva; Thurnheer Zürcher, Maria Christine; Günthard, Huldrych F; Khanna, Nina; Walker, Lucy Jane; Arancibia-Cárcamo, Carolina V; Newell, Evan W; Willberg, Christian B; Klenerman, Paul (2018). CD161 Defines a Functionally Distinct Subset of Pro-Inflammatory Natural Killer Cells. Frontiers in immunology, 9, p. 486. Frontiers Research Foundation 10.3389/fimmu.2018.00486

[img]
Preview
Text
fimmu-09-00486.pdf - Published Version
Available under License Creative Commons: Attribution (CC-BY).

Download (6MB) | Preview

CD161 is a C-type lectin-like receptor expressed on the majority of natural killer (NK) cells; however, the significance of CD161 expression on NK cells has not been comprehensively investigated. Recently, we found that CD161 expression identifies a transcriptional and innate functional phenotype that is shared across various T cell populations. Using mass cytometry and microarray experiments, we demonstrate that this functional phenotype extends to NK cells. CD161 marks NK cells that have retained the ability to respond to innate cytokines during their differentiation, and is lost upon cytomegalovirus-induced maturation in both healthy and human immunodeficiency virus (HIV)-infected patients. These pro-inflammatory NK cells are present in the inflamed lamina propria where they are enriched for integrin CD103 expression. Thus, CD161 expression identifies NK cells that may contribute to inflammatory disease pathogenesis and correlates with an innate responsiveness to cytokines in both T and NK cells.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Infectiology

UniBE Contributor:

Thurnheer Zürcher, Maria Christine

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1664-3224

Publisher:

Frontiers Research Foundation

Language:

English

Submitter:

Annelies Luginbühl

Date Deposited:

28 May 2018 15:12

Last Modified:

21 Jan 2019 09:08

Publisher DOI:

10.3389/fimmu.2018.00486

PubMed ID:

29686665

Uncontrolled Keywords:

CD161 cytomegalovirus human immunodeficiency virus inflammatory bowel diseases natural killer cells pro-inflammatory cytokines

BORIS DOI:

10.7892/boris.116491

URI:

https://boris.unibe.ch/id/eprint/116491

Actions (login required)

Edit item Edit item
Provide Feedback