Stroke causes a transient imbalance of interhemispheric information flow in EEG during non-REM sleep.

Zubler, Frédéric; Seiler, Andrea Barbara; Horvath, Thomas; Roth Wälti, Corinne; Miano, Silvia; Rummel, Christian; Gast, Heidemarie; Nobili, Lino; Schindler, Kaspar Anton; Bassetti, Claudio (2018). Stroke causes a transient imbalance of interhemispheric information flow in EEG during non-REM sleep. Clinical neurophysiology, 129(7), pp. 1418-1426. Elsevier 10.1016/j.clinph.2018.03.038

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OBJECTIVE Large-scale connectivity, especially interhemispheric connections, plays a crucial role for recovery after stroke. Here we used methods from information theory to characterize interhemispheric information flow in wake- and sleep-EEG after cerebral ischemia. METHODS 34 patients with unilateral ischemic stroke were included. Symbolic Transfer Entropy (STE) was applied between bipolar EEG signals on the left and the right cerebral hemisphere during polysomnographic recordings in the acute phase and 3 months after stroke. RESULTS In the acute phase, we found a sleep stage-dependent preferred interhemispheric asymmetry: during non-REM sleep the information flow was predominantly directed from the contralesional toward the ipsilesional hemisphere. This effect was greatly reduced in a follow-up recording 3 months after stroke onset. CONCLUSION Our findings are consistent with functional imaging studies showing a transient hyperactivity of contralesional areas after stroke. We conclude that STE is a robust method for detecting post-stroke connectivity reorganizations, and that sleep stages have to be taken into account when assessing functional connectivity. SIGNIFICANCE EEG is more widely available than functional MRI. Future studies will have to confirm whether EEG derived STE can be useful in a clinical setting during rehabilitation after stroke.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic and Interventional Neuroradiology

UniBE Contributor:

Zubler, Frédéric; Seiler, Andrea Barbara; Horvath, Thomas; Roth Wälti, Corinne; Miano, Silvia; Rummel, Christian; Gast, Heidemarie; Schindler, Kaspar Anton and Bassetti, Claudio

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1388-2457

Publisher:

Elsevier

Language:

English

Submitter:

Martin Zbinden

Date Deposited:

24 May 2018 11:32

Last Modified:

01 Jun 2018 01:32

Publisher DOI:

10.1016/j.clinph.2018.03.038

PubMed ID:

29730541

Uncontrolled Keywords:

Electroencephalography Functional connectivity NREM sleep Rehabilitation Sleep Stroke Symbolic transfer entropy

BORIS DOI:

10.7892/boris.116538

URI:

https://boris.unibe.ch/id/eprint/116538

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