Eosinophilic esophagitis: latest insights from diagnosis to therapy.

Schoepfer, Alain; Blanchard, Carine; Dawson, Heather; Lucendo, Alfredo; Mauro, Aurelio; Ribi, Camillo; Safroneeva, Ekaterina; Savarino, Edoardo V; Penagini, Roberto (2018). Eosinophilic esophagitis: latest insights from diagnosis to therapy. Annals of the New York Academy of Sciences, 1434(1), pp. 84-93. Blackwell 10.1111/nyas.13731

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Eosinophilic esophagitis (EoE) represents a chronic, local immune-mediated esophageal disease, characterized clinically by symptoms related to esophageal dysfunction and histologically by eosinophil-predominant inflammation. Other systemic and local causes of esophageal eosinophilia should be excluded. Clinical manifestations or pathologic data should not be interpreted in isolation. EoE was first described as a distinct disease entity in 1993. Most patients are diagnosed with underlying food allergies. The first diagnostic and therapeutic guidelines were published in 2007 with a first update in 2011. In 2017, new international guidelines were published based on the GRADE methodology. These guidelines provide, among many other topics, insights on the role of proton pump inhibitor-responsive esophageal eosinophilia. Over the last two decades, considerable progress was made by stakeholders regarding the understanding of EoE's pathogenesis, genetic background, natural history, allergy workup, standardization of assessment of disease activity, evaluation of minimally invasive diagnostic tools, and new therapeutic approaches. This brief review provides further insights into latest diagnostic and therapeutic advances.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine
04 Faculty of Medicine > Service Sector > Institute of Pathology

UniBE Contributor:

Dawson, Heather and Safroneeva, Ekaterina

Subjects:

600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services
500 Science > 570 Life sciences; biology

ISSN:

0077-8923

Publisher:

Blackwell

Language:

English

Submitter:

Tanya Karrer

Date Deposited:

16 May 2018 15:07

Last Modified:

15 Dec 2018 01:31

Publisher DOI:

10.1111/nyas.13731

PubMed ID:

29762879

Uncontrolled Keywords:

dysphagia eosinophilic esophagitis food allergy guidelines patient-reported outcomes proton pump inhibitor-responsive esophageal eosinophilia

BORIS DOI:

10.7892/boris.116564

URI:

https://boris.unibe.ch/id/eprint/116564

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