Guenat, Olivier Thierry; Berthiaume, François (2018). Incorporating mechanical strain in organs-on-a-chip: Lung and skin. Biomicrofluidics, 12(4), 042207. American Institute of Physics 10.1063/1.5024895
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Guenat Berthiaume 2018.pdf - Published Version Available under License Creative Commons: Attribution (CC-BY). Download (1MB) | Preview |
In the last decade, the advent of microfabrication and microfluidics and an increased interest in cellular mechanobiology have triggered the development of novel microfluidic-based platforms. They aim to incorporate the mechanical strain environment that acts upon tissues and in-vivo barriers of the human body. This article reviews those platforms, highlighting the different strains applied, and the actuation mechanisms and provides representative applications. A focus is placed on the skin and the lung barriers as examples, with a section that discusses the signaling pathways involved in the epithelium and the connective tissues.
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