Incorporating mechanical strain in organs-on-a-chip: Lung and skin

Guenat, Olivier Thierry; Berthiaume, François (2018). Incorporating mechanical strain in organs-on-a-chip: Lung and skin. Biomicrofluidics, 12(4), 042207. American Insitute of Physics 10.1063/1.5024895

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In the last decade, the advent of microfabrication and microfluidics and an increased interest in cellular mechanobiology have triggered the development of novel microfluidic-based platforms. They aim to incorporate the mechanical strain environment that acts upon tissues and in-vivo barriers of the human body. This article reviews those platforms, highlighting the different strains applied, and the actuation mechanisms and provides representative applications. A focus is placed on the skin and the lung barriers as examples, with a section that discusses the signaling pathways involved in the epithelium and the connective tissues.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Thoracic Surgery
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Pneumology
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10 Strategic Research Centers > ARTORG Center for Biomedical Engineering Research > ARTORG Center - Lung Regeneration Technologies

UniBE Contributor:

Guenat, Olivier Thierry

Subjects:

600 Technology > 610 Medicine & health
500 Science > 570 Life sciences; biology
600 Technology > 620 Engineering

ISSN:

1932-1058

Publisher:

American Insitute of Physics

Language:

English

Submitter:

Olivier Thierry Guenat

Date Deposited:

28 May 2018 16:50

Last Modified:

17 Jul 2019 11:17

Publisher DOI:

10.1063/1.5024895

PubMed ID:

29861818

BORIS DOI:

10.7892/boris.116627

URI:

https://boris.unibe.ch/id/eprint/116627

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