Goldberg, Johannes; Raabe, Andreas; Bervini, David (2018). Natural history of brain arteriovenous malformations: systematic review. Journal of Neurosurgical Sciences, 62(4), pp. 437-443. Edizione Minerva Medica 10.23736/S0390-5616.18.04452-1
Full text not available from this repository.INTRODUCTION
The appropriate interpretation of natural history of brain arteriovenous malformations (bAVMs) and of factors that negatively affect the risk of future hemorrhage are important when recommending management pathways. With the present systematic review, we aim to provide an overview of the available evidence on natural history of brain arteriovenous malformations (bAVMs), focusing on hemorrhage rates and risk factors for future hemorrhage.
EVIDENCE ACQUISITION
We performed a systematic literature analysis using the Ovid Medline database, encompassing English language studies (published between 1980 and 2018) reporting the natural history of untreated bAVMs. Annual hemorrhage rates in both unruptured and previously ruptured bAVMs, as well as risk factors for future hemorrhage were extracted for analysis.
EVIDENCE SYNTHESIS
Eighteen studies with a total of 8418 bAVM-cases could be extracted from the literature. Seventeen studies reported annual hemorrhage rates and ten studies reported risk factors for future hemorrhage. The average annualized hemorrhage rate was 2.2% for unruptured bAVMs and 4.3%, for bAVMs that presented with hemorrhage. Prior hemorrhage and deep AVM location could be identified as most consistently reported risk factors for future hemorrhage.
CONCLUSIONS
Previously ruptured bAVMs have a higher annual hemorrhage rate than enraptured bAVMs. Deep bAVM location and prior hemorrhage may increase the risk for subsequent hemorrhage.
Item Type: |
Journal Article (Review Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurosurgery |
UniBE Contributor: |
Goldberg, Johannes, Raabe, Andreas, Bervini, David |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0390-5616 |
Publisher: |
Edizione Minerva Medica |
Language: |
English |
Submitter: |
Nicole Söll |
Date Deposited: |
04 Jun 2018 12:37 |
Last Modified: |
05 Dec 2022 15:14 |
Publisher DOI: |
10.23736/S0390-5616.18.04452-1 |
PubMed ID: |
29595047 |
URI: |
https://boris.unibe.ch/id/eprint/116870 |
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