Adenosine and Ticagrelor Plasma Levels in Patients With and Without Ticagrelor-Related Dyspnea.

Ortega-Paz, Luis; Brugaletta, Salvatore; Ariotti, Sara; Akkerhuis, K Martijn; Karagiannis, Alexios; Windecker, Stephan; Valgimigli, Marco; Endotherlial function and other Circulating biomarkInvestigators, Hunting for the off-target properties of Ticagrelor on (2018). Adenosine and Ticagrelor Plasma Levels in Patients With and Without Ticagrelor-Related Dyspnea. Circulation, 138(6), pp. 646-648. Lippincott Williams & Wilkins 10.1161/CIRCULATIONAHA.118.034489

[img]
Preview
Text
Ortega-Paz Circulation 2018.pdf - Accepted Version
Available under License Publisher holds Copyright.

Download (679kB) | Preview
[img] Text
Ortega-Paz Circulation 2018.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (542kB) | Request a copy

Dyspnea is a common side effect of ticagrelor, leading to drug discontinuation in roughly one in every 20 treated patients. Studies have suggested that ticagrelor inhibits the sodium-independent equilibrative nucleoside transporter-1, which may increase adenosine plasma levels and explain drug-related dyspnea. However, the identification of a pattern of periodic breathing associated to increased chemosensitivity to hypercapnia in patients with ticagrelor-related dyspnea has reinforced the hypothesis that this side effect may result from direct inhibition of P2Y receptors on neurons leading to purinergic stimulation of the chemoreflex system. Simultaneous measurements of adenosine and ticagrelor plasma levels in patients with and without dyspnea while on treatment with ticagrelor may help unraveling the mechanism of this common and clinically relevant side effect.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine
04 Faculty of Medicine > Pre-clinic Human Medicine > CTU Bern

UniBE Contributor:

Ariotti, Sara; Karagiannis Voules, Alexios; Windecker, Stephan and Valgimigli, Marco

Subjects:

600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services

ISSN:

0009-7322

Publisher:

Lippincott Williams & Wilkins

Language:

English

Submitter:

Tanya Karrer

Date Deposited:

31 May 2018 12:10

Last Modified:

31 Oct 2019 08:09

Publisher DOI:

10.1161/CIRCULATIONAHA.118.034489

PubMed ID:

29794083

Additional Information:

Autor für Post-print angefragt. 31.5.2018/tka

Uncontrolled Keywords:

P2Y12 receptor adenosine dual antiplatelet therapy dyspnea respiration ticagrelor

BORIS DOI:

10.7892/boris.116912

URI:

https://boris.unibe.ch/id/eprint/116912

Actions (login required)

Edit item Edit item
Provide Feedback