Sex Differences in Recombination in Sticklebacks.

Sardell, Jason M; Cheng, Changde; Dagilis, Andrius J; Ishikawa, Asano; Kitano, Jun; Peichel, Catherine L; Kirkpatrick, Mark (2018). Sex Differences in Recombination in Sticklebacks. G3 Genes Genomes Genetics, 8(6), pp. 1971-1983. Genetics Society of America 10.1534/g3.118.200166

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Recombination often differs markedly between males and females. Here we present the first analysis of sex-specific recombination in sticklebacks. Using whole-genome sequencing of 15 crosses between and , we localized 698 crossovers with a median resolution of 2.3 kb. We also used a bioinformatic approach to infer historical sex-averaged recombination patterns for both species. Recombination is greater in females than males on all chromosomes, and overall map length is 1.64 times longer in females. The locations of crossovers differ strikingly between sexes. Crossovers cluster toward chromosome ends in males, but are distributed more evenly across chromosomes in females. Suppression of recombination near the centromeres in males causes crossovers to cluster at the ends of long arms in acrocentric chromosomes, and greatly reduces crossing over on short arms. The effect of centromeres on recombination is much weaker in females. Genomic differentiation between and is strongly correlated with recombination rate, and patterns of differentiation along chromosomes are strongly influenced by male-specific telomere and centromere effects. We found no evidence for fine-scale correlations between recombination and local gene content in either sex. We discuss hypotheses for the origin of sexual dimorphism in recombination and its consequences for sexually antagonistic selection and sex chromosome evolution.

Item Type:

Journal Article (Original Article)

Division/Institute:

08 Faculty of Science > Department of Biology > Institute of Ecology and Evolution (IEE) > Evolutionary Ecology
08 Faculty of Science > Department of Biology > Institute of Ecology and Evolution (IEE)

UniBE Contributor:

Peichel, Catherine L

Subjects:

500 Science > 570 Life sciences; biology

ISSN:

2160-1836

Publisher:

Genetics Society of America

Funders:

[UNSPECIFIED] US National Institutes of Health

Language:

English

Submitter:

Catherine Peichel

Date Deposited:

06 Jun 2018 16:05

Last Modified:

24 Oct 2019 06:52

Publisher DOI:

10.1534/g3.118.200166

PubMed ID:

29632132

Uncontrolled Keywords:

chromosome center biased differentiation genomic differentiation heterochiasmy recombination sex chromosomes

BORIS DOI:

10.7892/boris.117026

URI:

https://boris.unibe.ch/id/eprint/117026

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