On the Modulation of Brain Activation During Simulated Weight Bearing in Supine Gait-Like Stepping

Jaeger, Lukas; Marchal Crespo, Laura; Wolf, Peter; Luft, Andreas R.; Riener, Robert; Michels, Lars; Kollias, Spyros (2016). On the Modulation of Brain Activation During Simulated Weight Bearing in Supine Gait-Like Stepping. Brain topography, 29(1), pp. 193-205. Springer 10.1007/s10548-015-0441-7

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To date, the neurophysiological correlates of muscle activation required for weight bearing during walking are poorly understood although, a supraspinal involvement has been discussed in the literature for many years. The present study investigates the effect of simulated ground reaction forces (0, 20, and 40 % of individual body weight) on brain activation in sixteen healthy participants. A magnetic resonance compatible robot was applied to render three different levels of load against the feet of the participants during active and passive gait-like stepping movements. Brain activation was analyzed by the means of voxel-wise whole brain analysis as well as by a region-of-interest analysis. A significant modulation of brain activation in sensorimotor areas by the load level could neither be demonstrated during active nor during passive stepping. These observations suggest that the regulation of muscle activation under different weight-bearing conditions during stepping occurs at the level of spinal circuitry or the brainstem rather than at the supraspinal level.

Item Type:

Journal Article (Original Article)

Division/Institute:

10 Strategic Research Centers > ARTORG Center for Biomedical Engineering Research > ARTORG Center - Motor Learning and Neurorehabilitation
10 Strategic Research Centers > ARTORG Center for Biomedical Engineering Research > ARTORG Center - Gerontechnology and Rehabilitation

UniBE Contributor:

Marchal Crespo, Laura and Riener, Robert

Subjects:

600 Technology > 610 Medicine & health
600 Technology > 620 Engineering

ISSN:

0896-0267

Publisher:

Springer

Language:

English

Submitter:

Angela Amira Botros

Date Deposited:

11 Jul 2018 16:54

Last Modified:

25 Jul 2019 02:30

Publisher DOI:

10.1007/s10548-015-0441-7

PubMed ID:

26206204

BORIS DOI:

10.7892/boris.117114

URI:

https://boris.unibe.ch/id/eprint/117114

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