Microbiota in the oral subgingival biofilm is associated with obesity in adolescence

Zeigler, Cecilia C; Persson, G Rutger; Wondimu, Biniyam; Marcus, Claude; Sobko, Tanja; Modéer, Thomas (2012). Microbiota in the oral subgingival biofilm is associated with obesity in adolescence. Obesity, 20(1), pp. 157-64. Hoboken, N.J.: Wiley 10.1038/oby.2011.305

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To test the hypothesis whether microbiota in oral biofilm is linked with obesity in adolescents we designed this cross-sectional study. Obese adolescents (n = 29) with a mean age of 14.7 years and normal weight subjects (n = 58) matched by age and gender were examined with respect to visible plaque index (VPI%) and gingival inflammation (bleeding on probing (BOP%)). Stimulated saliva was collected. They answered a questionnaire concerning medical history, medication, oral hygiene habits, smoking habits, and sociodemographic background. Microbiological samples taken from the gingival crevice was analyzed by checkerboard DNA-DNA hybridization technique. The sum of bacterial cells in subgingival biofilm was significantly associated with obesity (P < 0.001). The link between sum of bacterial cells and obesity was not confounded by any of the studied variables (chronic disease, medication, VPI%, BOP%, flow rate of whole saliva, or meal frequency). Totally 23 bacterial species were present in approximately threefold higher amounts, on average, in obese subjects compared with normal weight controls. Of the Proteobacteria phylum, Campylobacter rectus and Neisseria mucosa were present in sixfold higher amounts among obese subjects. The association between obesity and sum of bacterial cells in oral subgingival biofilm indicates a possible link between oral microbiota and obesity in adolescents.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > School of Dental Medicine > Department of Periodontology

UniBE Contributor:

Persson, Gösta Rutger

ISSN:

1930-7381

Publisher:

Wiley

Language:

English

Submitter:

Eveline Carmen Schuler

Date Deposited:

04 Oct 2013 14:31

Last Modified:

25 Jan 2017 12:16

Publisher DOI:

10.1038/oby.2011.305

PubMed ID:

21996660

Web of Science ID:

000298401400018

URI:

https://boris.unibe.ch/id/eprint/11717 (FactScience: 217959)

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