The role of melanin-concentrating hormone in conditioned reward learning.

Sherwood, Andrew; Wosiski-Kuhn, Marlena; Nguyen, Truc; Holland, Peter C; Lakaye, Bernard; Adamantidis, Antoine Roger; Johnson, Alexander W (2012). The role of melanin-concentrating hormone in conditioned reward learning. European journal of neuroscience, 36(8), pp. 3126-3133. Blackwell Science 10.1111/j.1460-9568.2012.08207.x

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The orexigenic neuropeptide melanin-concentrating hormone (MCH) is well positioned to play a key role in connecting brain reward and homeostatic systems due to its synthesis in hypothalamic circuitry and receptor expression throughout the cortico-striatal reward circuit. Here we examined whether targeted-deletion of the MCH receptor (MCH-1R) in gene-targeted heterozygote and knockout mice (KO), or systemic treatment with pharmacological agents designed to antagonise MCH-1R in C57BL/6J mice would disrupt two putative consequences of reward learning that rely on different neural circuitries: conditioned reinforcement (CRf) and Pavlovian-instrumental transfer (PIT). Mice were trained to discriminate between presentations of a reward-paired cue (CS+) and an unpaired CS-. Following normal acquisition of the Pavlovian discrimination in all mice, we assessed the capacity for the CS+ to act as a reinforcer for new nose-poke learning (CRf). Pharmacological disruption in control mice and genetic deletion in KO mice impaired CRf test performance, suggesting MCH-1R is necessary for initiating and maintaining behaviors that are under the control of conditioned reinforcers. To examine a dissociable form of reward learning (PIT), a naïve group of mice were trained in separate Pavlovian and instrumental lever training sessions followed by the PIT test. For all mice the CS+ was capable of augmenting ongoing lever responding relative to CS- periods. These results suggest a role for MCH in guiding behavior based on the conditioned reinforcing value of a cue, but not on its incentive motivational value.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Adamantidis, Antoine Roger

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0953-816X

Publisher:

Blackwell Science

Language:

English

Submitter:

Stefanie Hetzenecker

Date Deposited:

28 Jun 2018 15:09

Last Modified:

23 Oct 2019 09:06

Publisher DOI:

10.1111/j.1460-9568.2012.08207.x

PubMed ID:

22775118

BORIS DOI:

10.7892/boris.117257

URI:

https://boris.unibe.ch/id/eprint/117257

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