Shining light on wakefulness and arousal.

de Lecea, Luis; Carter, Matthew E; Adamantidis, Antoine Roger (2012). Shining light on wakefulness and arousal. Biological psychiatry, 71(12), pp. 1046-1052. Elsevier 10.1016/j.biopsych.2012.01.032

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Alterations in arousal states are associated with multiple neuropsychiatric disorders, including generalized anxiety disorders, addiction, schizophrenia, and depression. Therefore, elucidating the neurobiological mechanisms controlling the boundaries between arousal, hyperarousal, and hypoarousal is a crucial endeavor in biological psychiatry. Substantial research over several decades has identified distinct arousal-promoting neural populations in the brain; however, how these nuclei act individually and collectively to promote and maintain wakefulness and various arousal states is unknown. We have recently applied optogenetic technology to the repertoire of techniques used to study arousal. Here, we discuss the recent results of these experiments and propose future use of this approach as a way to understand the complex dynamics of neural circuits controlling arousal and arousal-related behaviors.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Adamantidis, Antoine Roger

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0006-3223

Publisher:

Elsevier

Language:

English

Submitter:

Stefanie Hetzenecker

Date Deposited:

28 Jun 2018 14:43

Last Modified:

23 Oct 2019 06:42

Publisher DOI:

10.1016/j.biopsych.2012.01.032

PubMed ID:

22440618

BORIS DOI:

10.7892/boris.117258

URI:

https://boris.unibe.ch/id/eprint/117258

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