Tuning arousal with optogenetic modulation of locus coeruleus neurons.

Carter, Matthew E; Yizhar, Ofer; Chikahisa, Sachiko; Nguyen, Hieu; Adamantidis, Antoine Roger; Nishino, Seiji; Deisseroth, Karl; de Lecea, Luis (2010). Tuning arousal with optogenetic modulation of locus coeruleus neurons. Nature neuroscience, 13(12), pp. 1526-1533. Nature America 10.1038/nn.2682

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Neural activity in the noradrenergic locus coeruleus correlates with periods of wakefulness and arousal. However, it is unclear whether tonic or phasic activity in these neurons is necessary or sufficient to induce transitions between behavioral states and to promote long-term arousal. Using optogenetic tools in mice, we found that there is a frequency-dependent, causal relationship among locus coeruleus firing, cortical activity, sleep-to-wake transitions and general locomotor arousal. We also found that sustained, high-frequency stimulation of the locus coeruleus at frequencies of 5 Hz and above caused reversible behavioral arrests. These results suggest that the locus coeruleus is finely tuned to regulate organismal arousal and that bursts of noradrenergic overexcitation cause behavioral attacks that resemble those seen in people with neuropsychiatric disorders.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Adamantidis, Antoine Roger

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1097-6256

Publisher:

Nature America

Language:

English

Submitter:

Stefanie Hetzenecker

Date Deposited:

11 Jul 2018 16:46

Last Modified:

29 Oct 2019 05:06

Publisher DOI:

10.1038/nn.2682

PubMed ID:

21037585

BORIS DOI:

10.7892/boris.117261

URI:

https://boris.unibe.ch/id/eprint/117261

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