Optogenetic deconstruction of sleep-wake circuitry in the brain.

Adamantidis, Antoine Roger; Carter, Matthew C; de Lecea, Luis (2010). Optogenetic deconstruction of sleep-wake circuitry in the brain. Frontiers in molecular neuroscience, 2, p. 31. Frontiers Research Foundation 10.3389/neuro.02.031.2009

Preview

Text 031_2009.pdf - Published Version Available under License Creative Commons: Attribution (CC-BY). Download (831kB) | Preview

How does the brain regulate the sleep-wake cycle? What are the temporal codes of sleep and wake-promoting neural circuits? How do these circuits interact with each other across the light/dark cycle? Over the past few decades, many studies from a variety of disciplines have made substantial progress in answering these fundamental questions. For example, neurobiologists have identified multiple, redundant wake-promoting circuits in the brainstem, hypothalamus, and basal forebrain. Sleep-promoting circuits have been found in the preoptic area and hypothalamus. One of the greatest challenges in recent years has been to selectively record and manipulate these sleep-wake centers in vivo with high spatial and temporal resolution. Recent developments in microbial opsin-based neuromodulation tools, collectively referred to as "optogenetics," have provided a novel method to demonstrate causal links between neural activity and specific behaviors. Here, we propose to use optogenetics as a fundamental tool to probe the necessity, sufficiency, and connectivity of defined neural circuits in the regulation of sleep and wakefulness.

Interest & Impact

Downloads

196 since deposited on 11 Jul 2018
15 in the past 12 months

Citations

5 Citations in Web of Science ®
6 Citations in Scopus

Search

in Google Scholar™

Services

Actions (login required)

Edit item

Actions (login required)

Edit item