Optogenetic deconstruction of sleep-wake circuitry in the brain.

Adamantidis, Antoine Roger; Carter, Matthew C; de Lecea, Luis (2010). Optogenetic deconstruction of sleep-wake circuitry in the brain. Frontiers in molecular neuroscience, 2, p. 31. Frontiers Research Foundation 10.3389/neuro.02.031.2009

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How does the brain regulate the sleep-wake cycle? What are the temporal codes of sleep and wake-promoting neural circuits? How do these circuits interact with each other across the light/dark cycle? Over the past few decades, many studies from a variety of disciplines have made substantial progress in answering these fundamental questions. For example, neurobiologists have identified multiple, redundant wake-promoting circuits in the brainstem, hypothalamus, and basal forebrain. Sleep-promoting circuits have been found in the preoptic area and hypothalamus. One of the greatest challenges in recent years has been to selectively record and manipulate these sleep-wake centers in vivo with high spatial and temporal resolution. Recent developments in microbial opsin-based neuromodulation tools, collectively referred to as "optogenetics," have provided a novel method to demonstrate causal links between neural activity and specific behaviors. Here, we propose to use optogenetics as a fundamental tool to probe the necessity, sufficiency, and connectivity of defined neural circuits in the regulation of sleep and wakefulness.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Adamantidis, Antoine Roger

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1662-5099

Publisher:

Frontiers Research Foundation

Language:

English

Submitter:

Stefanie Hetzenecker

Date Deposited:

11 Jul 2018 16:04

Last Modified:

11 Jul 2018 16:13

Publisher DOI:

10.3389/neuro.02.031.2009

PubMed ID:

20126433

Uncontrolled Keywords:

hypocretins/orexins hypothalamus optogenetics sleep wakefulness

BORIS DOI:

10.7892/boris.117265

URI:

https://boris.unibe.ch/id/eprint/117265

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