Phasic firing in dopaminergic neurons is sufficient for behavioral conditioning.

Tsai, Hsing-Chen; Zhang, Feng; Adamantidis, Antoine Roger; Stuber, Garret D; Bonci, Antonello; de Lecea, Luis; Deisseroth, Karl (2009). Phasic firing in dopaminergic neurons is sufficient for behavioral conditioning. Science, 324(5930), pp. 1080-1084. American Association for the Advancement of Science 10.1126/science.1168878

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Natural rewards and drugs of abuse can alter dopamine signaling, and ventral tegmental area (VTA) dopaminergic neurons are known to fire action potentials tonically or phasically under different behavioral conditions. However, without technology to control specific neurons with appropriate temporal precision in freely behaving mammals, the causal role of these action potential patterns in driving behavioral changes has been unclear. We used optogenetic tools to selectively stimulate VTA dopaminergic neuron action potential firing in freely behaving mammals. We found that phasic activation of these neurons was sufficient to drive behavioral conditioning and elicited dopamine transients with magnitudes not achieved by longer, lower-frequency spiking. These results demonstrate that phasic dopaminergic activity is sufficient to mediate mammalian behavioral conditioning.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Adamantidis, Antoine Roger

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0036-8075

Publisher:

American Association for the Advancement of Science

Language:

English

Submitter:

Stefanie Hetzenecker

Date Deposited:

11 Jul 2018 15:52

Last Modified:

23 Oct 2019 11:22

Publisher DOI:

10.1126/science.1168878

PubMed ID:

19389999

BORIS DOI:

10.7892/boris.117268

URI:

https://boris.unibe.ch/id/eprint/117268

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