A role for Melanin-Concentrating Hormone in learning and memory.

Adamantidis, Antoine Roger; de Lecea, Luis (2009). A role for Melanin-Concentrating Hormone in learning and memory. Peptides, 30(11), pp. 2066-2070. Elsevier 10.1016/j.peptides.2009.06.024

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The neurobiological substrate of learning process and persistent memory storage involves multiple brain areas. The neocortex and hippocampal formation are known as processing and storage sites for explicit memory, whereas the striatum, amygdala, neocortex and cerebellum support implicit memory. Synaptic plasticity, long-term changes in synaptic transmission efficacy and transient recruitment of intracellular signaling pathways in these brain areas have been proposed as possible mechanisms underlying short- and long-term memory retention. In addition to the classical neurotransmitters (glutamate, GABA), experimental evidence supports a role for neuropeptides in modulating memory processes. This review focuses on the role of the Melanin-Concentrating Hormone (MCH) and receptors on memory formation in animal studies. Possible mechanisms may involve direct MCH modulation of neural circuit activity that support memory storage and cognitive functions, as well as indirect effect on arousal.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Adamantidis, Antoine Roger

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0196-9781

Publisher:

Elsevier

Language:

English

Submitter:

Stefanie Hetzenecker

Date Deposited:

11 Jul 2018 15:48

Last Modified:

05 Nov 2019 08:01

Publisher DOI:

10.1016/j.peptides.2009.06.024

PubMed ID:

19576257

BORIS DOI:

10.7892/boris.117269

URI:

https://boris.unibe.ch/id/eprint/117269

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