The hypocretins as sensors for metabolism and arousal.

Adamantidis, Antoine Roger; de Lecea, Luis (2009). The hypocretins as sensors for metabolism and arousal. Journal of physiology, 587(1), pp. 33-40. Wiley-Blackwell 10.1113/jphysiol.2008.164400

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Sleep disturbances are associated with hormonal imbalances and may result in metabolic disorders including obesity and diabetes. Therefore, circuits controlling both sleep and metabolism are likely to play a role in these physiopathological conditions. The hypocretin (Hcrt) system is a strong candidate for mediating both sleep and metabolic imbalances because Hcrt neurons are sensitive to metabolic hormones, including leptin and ghrelin, and modulate arousal and goal-orientated behaviours. This review discusses the role of Hcrt neurons as a sensors of energy balance and arousal and proposes new ways of probing local hypothalamic circuits regulating sleep and metabolism with unprecedented cellular specificity and temporal resolution.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Adamantidis, Antoine Roger

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0022-3751

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Stefanie Hetzenecker

Date Deposited:

11 Jul 2018 15:59

Last Modified:

11 Jul 2018 16:09

Publisher DOI:

10.1113/jphysiol.2008.164400

PubMed ID:

19047201

BORIS DOI:

10.7892/boris.117270

URI:

https://boris.unibe.ch/id/eprint/117270

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