Adamantidis, Antoine Roger; de Lecea, Luis (2009). The hypocretins as sensors for metabolism and arousal. Journal of physiology, 587(1), pp. 33-40. Wiley-Blackwell 10.1113/jphysiol.2008.164400
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Sleep disturbances are associated with hormonal imbalances and may result in metabolic disorders including obesity and diabetes. Therefore, circuits controlling both sleep and metabolism are likely to play a role in these physiopathological conditions. The hypocretin (Hcrt) system is a strong candidate for mediating both sleep and metabolic imbalances because Hcrt neurons are sensitive to metabolic hormones, including leptin and ghrelin, and modulate arousal and goal-orientated behaviours. This review discusses the role of Hcrt neurons as a sensors of energy balance and arousal and proposes new ways of probing local hypothalamic circuits regulating sleep and metabolism with unprecedented cellular specificity and temporal resolution.
Item Type: |
Journal Article (Review Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology |
UniBE Contributor: |
Adamantidis, Antoine Roger |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0022-3751 |
Publisher: |
Wiley-Blackwell |
Language: |
English |
Submitter: |
Stefanie Hetzenecker |
Date Deposited: |
11 Jul 2018 15:59 |
Last Modified: |
05 Dec 2022 15:14 |
Publisher DOI: |
10.1113/jphysiol.2008.164400 |
PubMed ID: |
19047201 |
BORIS DOI: |
10.7892/boris.117270 |
URI: |
https://boris.unibe.ch/id/eprint/117270 |
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